Spatiotemporal control over the delivery of therapeutic agents is an outstanding challenge to cancer treatment. By taking advantage of recent advances in DNA aptamer biology and mesoporous silica nanotechnology, we report a general approach to design and fabricate controlled release drug delivery systems that are able to effectively target cancer cells. Specifically, polyvalent mesoporous silic...

Mesoporous silica-based nanoparticles are generally accepted as a potential platform for drug loading with a lot of advantages, except for their complex purification procedures and structures that are difficult to decompose. In this work, biocompatible hyperbranched polyglycerol is introduced to synthesize mesoporous silica nanoparticles (MSNs). The materials possess good biocompatibility, cont...

A family of mesoporous nonprecious metal (NPM) catalysts for oxygen reduction reaction (ORR) in acidic media, including cobalt-nitrogen-doped carbon (C-N-Co) and iron-nitrogen-doped carbon (C-N-Fe), was prepared from vitamin B12 (VB12) and the polyaniline-Fe (PANI-Fe) complex, respectively. Silica nanoparticles, ordered mesoporous silica SBA-15, and montmorillonite were used as templates for ac...

Recently, there has been great interest in the synthesis and application of various kinds of nanostructured noble metals such as platinum, gold and silver. Nanostructured silvers have been widely investigated as antimicrobial materials, bio-sensors, catalysts, and advanced materials exhibiting surface plasmon resonance and surface enhanced Raman scattering. All this research is mainly based on ...

Silicotungstenic acid (STA)-containing mesoporous materials were directly synthesized in a nonaqueous medium by sol-gel method. X-ray powder diffraction showed that both as-synthesized and calcined materials possess mesoporous structure. STA contents in extraction solutions were analyzed with inductively coupled plasma. When STA/silica ratio changed from 1:100 to 1:4, the immobilization of STA ...

Three periodic mesoporous materials, i.e., two organosilicas with either ethylene or phenylene bridges and one silica, have been used as supports for Pd nanoparticles. All Pd-supported samples (1.0 wt%) were prepared by the incipient wetness method and subsequently reduced in an H₂ stream at 200 °C. Both hydrogen chemisorption and temperature programmed reduction experiments revealed significan...

N-alkylation reaction of amine functionalized phenylene moieties in crystal-like mesoporous silica is successfully achieved with about 87% of conversion in two reaction cycles. A potassium iodide catalyzed method commonly used for the selective N-monoalkylation of aniline is adapted and optimized to the N-monoalkylation reactions of the amine functionalized periodic mesoporous phenylene-silica ...

BACKGROUND Inorganic mesoporous materials exhibit good biocompatibility and hydrothermal stability for cell immobilization. However, it is difficult to encapsulate living cells under mild conditions, and new strategies for cell immobilization are needed. We designed a "fish-in-net" approach for encapsulation of enzymes in ordered mesoporous silica under mild conditions. The main objective of th...

During last years the interest for nanotechnology and mesoporous silica materials has increased due to benefits that these materials can provide. Typical characteristics of mesoporous materials are a large surface area and pore volume, well-ordered and uniform pores with adjustable pores between 2 and 50 nm. Pore dimensions are comparable to many biological molecules, like enzymes, and may ther...

Mesoporous silica nanoparticles (MSNs) containing vinyl-, propyl-, isobutyl- and phenyl functionalized monolayers were reported. These functionalized MSNs were prepared via molecular self-assembly of organosilanes on the mesoporous supports. The relative surface coverage of the organic monolayers can reach up to 100% (about 5.06 silanes/nm.