Non-alcoholic fatty liver disease (NAFLD) continues to rise and has become the most common cause of chronic among all ages ethnicities. Metabolic disorders, such as obesity insulin resistance, are closely associated with sarcopenia NAFLD. Sarcopenic is a clinical disorder characterized by simultaneous loss skeletal muscle gain adipose tissue. It worse outcomes in individuals projected that NAFL...

Chronic stress is well known to affect metabolic regulation. However, molecular mechanisms interconnecting stress response systems and metabolic regulations have yet to be elucidated. Various physiological processes, including glucose/lipid metabolism, are regulated by the circadian clock, and core clock gene dysregulation reportedly leads to metabolic disorders. Glucocorticoids, acting as end-...

The human gut is the largest organ with immune function in our body, responsible for regulating homeostasis of intestinal barrier. A diverse, complex and dynamic population microorganisms, called microbiota, which exert a significant impact on host during disease, supports this role. In fact, bacteria maintain metabolic homeostasis, protecting organism against pathogens. development numerous in...

The objectives of this study were to examine the effects varying dietary energy supply as well impacts subclinical ketosis (SCK) on blood chemistry and liver health. A total 63 German-Holstein cows housed from three weeks antepartum until sixteen postpartum. After calving, assigned one four treatment groups receiving either moderate or high concentrations in roughage secondly amounts concentrat...

Lipids excess from an uterine environment can increase free radicals production of and thus induce oxidative status imbalance, a key factor for progression non-alcoholic fatty liver disease (NAFLD) in offspring. Food antioxidant components maternal diet may play important role preventing offspring metabolic disorders. The objective the study was to evaluate effects açaí pulp supplementation on ...

the worldwide prevalence of insulin resistant states such as the metabolic syndrome has grown rapidly over the past few decades. the metabolic syndrome is a constellation of common metabolic disorders that promote the development of atherosclerosis and cardiovascular disease. studies in both human and animal models suggest that hepatic inflammation and insulin resistance are key initiating fact...

Many metabolic liver disorders are refractory to drug therapy and require orthotopic liver transplantation. Here we demonstrate a new strategy, which we call metabolic pathway reprogramming, to treat hereditary tyrosinaemia type I in mice; rather than edit the disease-causing gene, we delete a gene in a disease-associated pathway to render the phenotype benign. Using CRISPR/Cas9 in vivo, we con...

Objective of the Review: To analyse available information on various aspects non-alcoholic fatty liver disease (NAFLD). Key Points. A group international experts proposed to replace terms “NAFLD” with “metabolism-associated disease” (MAFLD) which, in opinion experts, more adequately reflects nature disease. The proposal is related fact that associated multi system disorders and a heterogeneous ...

The liver is a central regulator of systemic energy homeostasis and has a pivotal role in glucose and lipid metabolism. Impaired gluconeogenesis and dyslipidemia are often observed in patients with nonalcoholic fatty liver disease (NAFLD). The liver is now recognized to be an endocrine organ that secretes hepatokines, which are proteins that regulate systemic metabolism and energy homeostasis. ...