metabolic pathway

Yoshimi Okamoto-Uchida Ruoxing Yu Norio Miyamura Norie Arima Mari Ishigami-Yuasa Hiroyuki Kagechika Suguru Yoshida Takamitsu Hosoya Makiko Nawa Takeshi Kasama Yoichi Asaoka Reiner Wimmer Alois Ulrich Elling Josef M. Penninger Sachiko Nishina Noriyuki Azuma Hiroshi Nishina

The primitive streak in peri-implantation embryos forms the mesoderm and endoderm and controls cell differentiation. The metabolic cues regulating primitive streak formation remain largely unknown. Here we utilised a mouse embryonic stem (ES) cell differentiation system and a library of well-characterised drugs to identify these metabolic factors. We found that statins, which inhibit the mevalo...

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Metabolic engineering

2010

Lawrence P. Wackett

MetaCyc database http://metacyc.org/ MetaCyc is a database of metabolic pathways containing more than 1400 pathways from more than 1800 organisms. KEGG pathway database http://www.genome.jp/kegg/pathway.html The KEGG pathway database consists of a collection of manually-curated metabolic maps with connections to metabolite, enzyme and organismal data. KEGG also contains tools for reconstructing...

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