et al. Clinical response and pharmacokinetics from a phase 1 study of an active dosing schedule of flavopiridol in relapsed chronic lymphocytic leukemia. Phase II study of flavopiridol in relapsed chronic lymphocytic leukemia demonstrating high response rates in genetically high-risk disease. a multicenter, international, phase 2 study of alvocidib for patients with fludarabine-refractory chron...

A series of six new aluminum(III) complexes with o-metalated arylimine ligands [o-C6H4(CH]NR') (R' 1⁄4 2,6-iPr2C6H3, 2,6-Me2C6H3)] have been synthesized from the reactions of R2AlCl (R 1⁄4Me, Et) with oC6H4(CH]NR')Li (R' 1⁄4 2,6-iPr2C6H3, 2,6-Me2C6H3, t-Bu) in pentane. The complexes all have 4 coordinate pseudo-tetrahedral aluminum centers ligated by two alkyl groups and one bidentate ligand mo...

Several reactions mediated by lithium diisopropylamide (LDA) with added hexamethylphosphoramide (HMPA) are described. The N-isopropylimine of cyclohexanone lithiates via an ensemble of monomer-based pathways. Conjugate addition of LDA/HMPA to an unsaturated ester proceeds via di- and tetra-HMPA-solvated dimers. Deprotonation of norbornene epoxide by LDA/HMPA proceeds via an intermediate metalat...

In the title compound, [Ir(C(10)H(8)N(3))(C(11)H(8)N)(2)], the Ir center is octa-hedrally coordinated by the three chelating ligands, with two cyclo-metalated 2-pyridylphenyl ligands [Ir-N = 2.049 (5) and 2.030 (5) Å; Ir-C = 2.016 (6) and 2.012 (6) Å] and a bidentate 2-(phenyl-diazen-yl)pyrrolate ligand [Ir-N = 2.204 (5) and 2.079 (5) Å]. The Ir-N(diazen-yl) bond is longer than the Ir-N(pyrrola...

Palladium-metalated PCN-222 enables the aerobic photo-oxidative cross-condensation of anilines with benzylic amines yielding a series linear and cyclic imines. The reaction is very efficient under mild conditions, which allows isolation simple, yet elusive, intermediates such as 2-(benzylideneamino)aniline 2-(benzylideneamino)phenols. Recyclability studies show excellent activity selectivity af...