نتایج جستجو برای: metallo beta lactamases mbl
تعداد نتایج: 193362 فیلتر نتایج به سال:
A screening study of the presence of metallo-beta-lactamases (IMP and VIM types and SPM-1) in isolates from different nonhospital sources was conducted, and it revealed the presence of bla(VIM-2), associated with the In58 class 1 integron, in two unrelated Pseudomonas aeruginosa strains from aquatic habitats. The results suggest that the hospital setting was the possible origin of these bla(VIM...
64 Rev Esp Quimioter 2010;23(2):100-102 The class B metallo carbapenem-hydrolyzing ß lactamases (MBLs) are enzymes of great concern because they possess activity against all ß -lactams, except monobactams. Up to now, several members of this family of enzymes have been described (IMP, VIM, SPM-1, GIM-1, SIM-1). Most of VIM and IMP genes usually reside within class 1 integrons as gene cassettes. ...
Metallo-β-lactamases (MBLs) are a family of Zndependent enzymes that have contributed strongly to the emergence and spread of antibiotic resistance. Novel members as well as variants of existing members of this family are discovered continuously, compounding their threat to global health care. MBLs are divided into three subgroups, i.e. B1, B2 and B3. The recent discovery of an unusual MBL from...
background : pseudomonas aeruginosa is a severe challenge for antimicrobial therapy, because of chromosomal mutations or exhibition of intrinsic resistance to various antimicrobial agents such as most β-lactams. we undertook this study to evaluate the existence of sme, aim and vim metallo-beta lactamases encoding genes among p. aeruginosa strains isolated from icu patients in al-zahra hospit...
This study determined the presence of Amp C beta lactamase producing Pseudomonas aeruginosa among the seventy four uropathogens studied using standard techniques. Results obtained revealed that the studied isolates show an alarming rate of resistance to the extended spectrum beta lactam antibiotics and the penicillin derivatives tested. The combination of piperacillin and tazobactam was however...
Resistance to β-lactam antibiotics mediated by metallo-β-lactamases (MBLs) is a growing problem. We describe the use of protein-observe 19 F-NMR (PrOF NMR) to study the dynamics of the São Paulo MBL (SPM-1) from β-lactam-resistant Pseudomonas aeruginosa. Cysteinyl variants on the α3 and L3 regions, which flank the di-ZnII active site, were selectively 19 F-labeled using 3-bromo-1,1,1-trifluoroa...
Background and Objective: Pseudomonas aeruginosa is an opportunistic pathogen and one of the most frequent pathogens in nosocomial infections. This bacterium shows high resistance to majority of antibiotics including â-lactams. The aim of this study was to investigate the pattern of antimicrobial resistance and evaluation of IMP, SPM and SIM Metallo- Beta- Lactamase producing Pseudomonas aerugi...
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