INTRODUCTION Tricyclic antidepressants are used in the treatment of various pain syndromes. The antidepressant clomipramine inhibits predominantly the reuptake of serotonin in the central nervous system. The mechanism of its analgesic effect is not fully understood. The AIM of the present study was to find experimentally any dose-effect dependence in the analgesic effect of clomipramine and the...

Dear Editors, Vascular leg ulcers are a very common disease with a complicated management, a significant sanitary expense, as well as a significant repercussion in patient’s quality of life. An appropriate analgesic control is essential for the management of this condition. Themost commonly used therapeutic options to treat the pain are oral analgesics (Non-Steroidal Anti-Inflammatory Drugs (NS...

BACKGROUND Mini-incision donor nephrectomies (MIDNs) were established during the last decade, as an alternative to traditional open donor nephrectomy (ODN) via flank incision. In this study, we investigated intra-operative and post-operative data on outcome following MIDN in comparison with ODN data. METHODS Data of 70 living kidney donations, performed at the University of Regensburg Medical...

In this issue of the British Journal Anaesthesia, Stamer and colleagues1Stamer U. Bernhart K. Lehman T. et al.Desire for more analgesic treatment: pain patient-reported outcome after paediatric tonsillectomy appendectomy.Br J Anaesth. 2021; 126: 1182-1191Abstract Full Text PDF Scopus (6) Google Scholar highlight that not all centres routinely administer intraoperative multimodal analgesia open ...

An 80-year-old woman with a weight of 74 kg had been primarily diagnosed with complex partial seizures secondary to severe cerebrovascular disease; she also had atrial fibrillation, peripheral artery disease, untreated high blood pressure, and advanced cognitive impairment – she only utters isolated words with a tendency to echolalia. She had an acute thromboembolic stroke two years ago, which ...

The semisynthetic derivative of camptothecin, irinotecan (CPT-11), has been used extensively as second-line chemotherapy for metastatic colorectal carcinoma resistant to 5-fluorouracil (5FU) and has also been studied in other tumor types (1–3). The toxic effects of irinotecan mainly consist of neutropenia, diarrhea, and cholinergic-like syndrome. Other toxic effects include alopecia, nausea and...

Accessible online at: www.karger.com/journals/res Drug-induced side effects are a very common medical problem. Their prevalence has not been systematically assessed, but there are reports of approximately 2% adverse reactions among hospitalized patients [1]. Among all adverse reactions to drugs which lead to only mild symptoms and which are successfully treated by simply withdrawing the drug in...

Introduction The complex pharmacodynamic mechanism of topiramate is currently approved for only two major diseases: epilepsy, mono or combined therapy, and preventing episodes of migraine. However, there are many other studies that emphasize other potential clinical effects deriving from its complex action and leading to its use in acute nociceptive pain and neuropathic pain management. Topiram...

Venom immunotherapy (VIT) is the only highly effective way of treating patients with hymenoptera venom allergy (HVA). The most serious anaphylactic symptoms of HVA (HVA-SYS IVo) are life-threatening, thus making their occurrence an unconditional recommendation for VIT. Yet, VIT is contraindicated in immune-mediated inflammatory diseases. We present the case of a 55-year-old woman with autoinfla...