Capecitabine is an important drug in the therapeutic armamentarium for metastatic breast cancer. A comprehensive worldwide clinical trial program involving >10,000 patients with locally advanced and metastatic breast cancer has provided evidence for the current treatment strategies. On the basis of data demonstrating consistent activity across several trials in patients with heavily pretreated ...

Gastric cancer has been known as a poor prognosis disease with a high degree of mortality. In Iran, it has been increased during the previous two decades, especially in northern part of the country. The aim of this study was to determine the demographic and clinical characteristics of gastric cancer in Mazandaran province. All patients with gastric cancer diagnosis treated in the Imam Khomeini ...

The virtual lack of well-characterized metastatic pancreatic cancer tissues for study has limited systematic studies of the metastatic process of this deadly disease. To address this important issue, we have instituted a rapid autopsy protocol for the collection of high quality tissues from patients with metastatic pancreatic cancer, called the Gastrointestinal Cancer Rapid Medical Donation Pro...

INTRODUCTION Altered serum microRNA (miRNA) levels may be correlated with a dysregulated expression pattern in parental tumor tissue and reflect the clinical evolution of disease. The overexpression of miR-21, miR-10b, and miR-19a is associated with the acquisition of malignant characteristics (increased tumor cell proliferation, migration, invasion, dissemination, and metastasis); thus, we det...

The advent of targeted agents, such as enfortumab vedotin, erdafitinib, and sacituzumab govitecan, have revolutionized the treatment metastatic urothelial cancer. Although these novel therapies demonstrated favorable efficacy outcomes, their toxicity must be carefully monitored. NCCN Guidelines for Bladder Cancer recommend platinum-based chemotherapy in this clinical context, but combination im...

BACKGROUND A previous study demonstrated that Fourier transform infrared (FTIR) spectroscopy can distinguish thyroid cancer from benign thyroid lesions. The aim of this study was to explore the use of FTIR for identifying metastatic lymph nodes of papillary thyroid cancer in vitro, and distinguishing between metastatic and non-metastatic tissue. METHODS Some 184 freshly removed cervical lymph...

Exercise can reduce the risk of death in men with prostate cancer. Although effect was demonstrated over 10 years ago, exercise medicine is still not recognised as a critical therapy cancer management. Nevertheless, evidence base building, and an ongoing randomised controlled trial has been designed to assess whether targeted highly sophisticated intervention causes survival advantage metastati...

A seventeen-year-old Jehovah’s witness with metastatic Ewing sarcoma initially declined cancer therapy due to the risk of life-threatening bone marrow suppression. He then subsequently agreed other treatment options bloodless supportive care measures in order achieve quality life and long-term control his disease. This case report adds collective knowledge providing including for patients cancer.

Up to one third of patients with breast cancer will show evidence of metastatic spread over their course of disease. Common sites of metastasis in breast cancer, in addition to axillary and supraclavicular lymph nodes, include bone, liver, lung, pleura (with associated pleural effusion), brain, skin, gynecologic organs, and GI tract, although any anatomic site can be the potential target. Most ...

background: the sentinel lymph node (sln) is defined as the first chain node in the lymphatic basin that receives primary lymphatic flow. if the sln is negative for metastatic disease, then other nodes are expected to be disease-free. sln techniques have been extensively applied in the staging and treatment of many tumors, including melanoma, breast and vulvar cancers. this study aims to evalua...