A method was developed for extracting, identifying, and quantifying diphenylamine (DPA) derivatives in the peel of DPA-treated apples using gradient reversed-phase liquid chromatography with ultraviolet-visible absorption and atmospheric pressure chemical ionization detection (LC-UV-vis-APCI-MS). Compounds routinely analyzed using this method included hydroxylated, nitrosated, nitrated, and met...

uitously found in plants. Fruits and vegetables, as well as popular beverages such as wine, tea, and coffee, are the main dietary sources of flavonoids. It has been reported that flavonoids show pharmacological effects such as antioxidant, antiviral, antitumor, and antiinflammatory activities. In particular, their antioxidant activity has attracted much attention as a possible dietary preventiv...

Background Flavonoids are well known for their vasodilatation activity. Their mechanism of action is still to be elucidated. Bilitranslocase is a bilirubin-specific membrane carrier that is also responsible for the ATP-independent transport of flavonoids across the cell membrane [1]. Recently, the expression of bilitranslocase in the endothelium has been characterized [2]. The aim of the study ...

The application of the Suzuki-Miyaura reaction in the synthesis of flavonoids, an important class of natural products, is reviewed. This reaction has not only been employed to provide access to flavonoid nuclei, but has also been applied to the synthesis of dimeric flavonoids and in the synthesis of libraries of flavonoid derivatives for biological activity studies. The classes of flavonoids th...

The flavonoids present in beeswax produced in “La Alcarria” region were analyzed by HPLC. Pinocembrin, pinobanksin, pinobanksin 3-acetate, chrysin, galangin and techtochrysin were detected as the main flavonoid constituents. This is the first detailed report on the flavonoids o f beeswax. These substances are already present when wax scales are secreted by bees. The same flavonoid compounds wer...

The synthesis of per-sulfated flavonoids, organic compounds with multiple sulfate groups, is challenging. We present here a two-step synthesis of fully sulfated flavonoids in high overall yields using the 2,2,2-trichloroethyl moiety as a protecting group. The two-step synthesis results in exclusive formation of the per-sulfated product in contrast to common sulfating agents that yield different...

diseases of heart and stroke cause most deaths in both sexes of all ethnic groups. for more than 40 years epidemiological studies, experimental studies, and clinical trials have shown that numerous dietary risk factors affect serum lipids, atherogenesis and coronary heart disease (chd). substantial interest has recently focused on the hypothesis that the naturally occurring antioxidant vitamins...