The synthesis, proof of structure, and the absorption and fluorescence properties of two new unsymmetrical cyanine dyes, thiazole orange dimer (TOTO; 1,1'-(4,4,7,7-tetramethyl-4,7- diazaundecamethylene)-bis-4-[3-methyl-2,3-dihydro-(benzo-1,3-thiaz ole)-2- methylidene]-quinolinium tetraiodide) and oxazole yellow dimer (YOYO; an analogue of TOTO with a benzo-1,3-oxazole in place of the benzo-1,3-...

Owing to their potent cytotoxicity against tumor cells, including taxol (paclitaxel)-resistant cell lines, the epothilones (for example, epothilone A (1) and epothilone B (2)) continue to be the focus of intense chemical, biological, and clinical research efforts around the world. 3] Following the findings that cyclopropane-, methylsulfanylthiazole-, and pyridine-containing epothilone B derivat...

Thiamine pyrophosphate is an essential cofactor that is synthesized de novo in Salmonella typhimurium. The biochemical steps and gene products involved in the conversion of aminoimidazole ribotide (AIR), a purine intermediate, to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine (HMP) moiety of thiamine have yet to be elucidated. We have isolated mutations in a new locus (Escherichia coli open re...

Exciton interactions between thiazole orange and thiazole red as nucleotide substitutes in DNA hairpins interfere with efficient energy transfer and fluorescence color change as readout. This interference can be tuned by two structural parameters that control the hairpin duplex stability.

background and objectives: bacterial resistance to antibiotics has motivated the researchers to evaluate the novel anti-bac- terial compounds such as some thiazole and imidazole derivatives. thereby, in this work, we investigated the anti-bacterial effects of one new thiazole and two new imidazole derivatives on bacillus cereus , listeria monocytogenes , escherichia coli, salmonella typhimurium...

The synthesis and structural characterisation of phosphine-substituted alkynylboronates is reported. A P(III)-centred alkynylboronate (2) was prepared that showed little evidence for the conjugation of the P-lone pair to the boron via the alkyne π-system, as judged by X-ray crystallography studies of 2 and a related P(V) compound, 3. In addition, corresponding alkynyltrifluoroborate salts were ...

Purpose: To evaluate the effects of herbal-based toothpastes with different contents on viability L929 cells.Methods: Herbal-based {Aloe vera - propolis herbal toothpaste, Group 1; Parodontax, 2; Toothpaste miswak, and tea tree extract, 3, Dent natural protective toothpaste clay, 4; Gano fresh, 5} were diluted (1:1, 1:2, 1:4, 1:8, 1:16, 1:32) in Dulbecco’s modified Eagle’s medium. fibroblast ce...

Aq4{5-Nitro-2-furyl)-2-thiazolyl]acetamide (NFTA), fed to female Swiss mice at doses of 0.05 and 0.1% of the diet, induced a high incidence of lymphocytic leukemia and a low incidence of forestomach tumors. Several other chemicals structurally related to NFTA were also fed to female Swiss mice to determine structure-activity relationships with respect to organ specificity. 7V-[4-(5-Nitro-2-fury...