Objective: The aim of presented study was to develop a high-performance liquid chromatography (HPLC) method with UV detection for simultaneous determination of ketoprofen, methyl paraben and propyl paraben in a gel formulation. Methods: The chromatography was carried out on a C18 Results: Under these chromatographic conditions, the obtained retention times were approximately 2.41 min for methyl...

BACKGROUND Limited data are available to assess human exposure to thousands of chemicals currently in commerce. Information that relates human intake of a chemical to its production and use can help inform understanding of mechanisms and pathways that control exposure and support efforts to protect public health. OBJECTIVES We introduce the intake-to-production ratio (IPR) as an economy-wide ...

Identification of early perturbations induced in cells from non-cancerous breast tissue is critical for understanding possible breast cancer risk from chemical exposure. We have demonstrated previously that exposure to the ubiquitous xenoestrogens, bisphenol A (BPA) and methyl paraben, promotes the hallmarks of cancer in non-malignant human high-risk donor breast epithelial cells (HRBECs) isola...

Five phenolic compounds, 4-hydroxybenzoic acid methyl ester (1), vanillic acid methyl ester (2), 4-hydroxy benzaldehyde (3), 4-hydroxybenzoic acid (4) and ferulic acid (5), and four flavonoids, 5,5'-dihydroxy-4',6,7-trimethoxyflavanone (6), luteolin (7), vitexicarpin (8) and artemetin (9), were isolated from fruits and leaves of Vitex rotundifolia L. The biological activities of these nine comp...

A method for the simultaneous determination of six preservatives in cosmetic and pharmaceutical products, as well as in surface waters, using high performance liquid chromatography (HPLC) has been developed. Methylisothiazolinone (MI), chloromethylisothiazolinone (CMI), benzyl alcohol (BA), potassium sorbate (PS), sodium benzoate (SB), and methylparaben (MP) were separated on a Develosil RP Aqu...

Chemicals such as phthalates, parabens, bisphenol A (BPA) and triclosan (TCS), used in a wide variety of consumer products, are suspected endocrine disrupters although their level of toxicity is thought to be low. Combined exposure may occur through ingestion, inhalation and dermal exposure, and their toxic as well as combined effects are poorly understood. The objective of the study was to est...

A non-atopic 74-year-old man complained of itching vesicular dermatitis on the left side of his thorax, which had flared up 8 days earlier, after a prolonged ECG monitoring. On inspection, many tense erythematous vesicular lesions, strictly arranged in a ring-shape, were observed at every site of application of the electrodes (Fig. 1). Due to the particular shape of the dermatitis a suction rea...

Low temperature vacuum drying is an alternative to sterile dry filling as a formulation approach for certain ethanol soluble substances that are poorly soluble or unstable in aqueous media. To date this ap­ proach has been limited to formulations containing the drug per se. However, several substances appear suitable as excipients in­ cluding urea, polyethylene glycol 4000, ascorbic acid, methy...