Natural Killer (NK) cells are large granular lymphocytes that are uniquely equipped to promote the anti-tumor response via communication with other immune cell types in the tumor microenvironment. We have shown that NK cells secrete a distinct profile of immune stimulatory factors e.g., interferon-gamma (IFN-g) with potent anti-tumor activity in response to dual stimulation with antibody (Ab)-c...

Organic nanodots of a cation radical salt of amphiphilic bis-TTF annulated macrocycle derivative were fabricated on mica surface by cast technique. The nanodots, whose diameter and height of nanodots depended on the surface positions, were arranged on mica surface during the solvent evaporation process.

MICA-129 polymorphism affects the binding affinity of MICA molecules with the NKG2D receptor and influences effector cell function. The genotype met/met was associated with the severity of left ventricular systolic dysfunction (LVSD) in patients with chronic Chagas heart disease, while the val/val genotype was associated with the absence of LVSD.

REE (LREE) into the glass with respect to clinopyroxene, but the A group of chrome-spinel peridotite upper-mantle xenoliths from the reverse for Sr and Y, in both mica-bearing and mica-free parageneses. Lashaine volcano, northern Tanzania, differs from other xenoliths In a mica-bearing melt pocket, Rb and Ba partition preferentially at this locality in containing glassy melt pockets. Modal, min...

This paper reports a study of the deposition process of DNA molecules onto a mica surface for imaging under the scanning force microscope (SFM). Kinetic experiments indicate that the transport of DNA molecules from the solution drop onto the surface is governed solely by diffusion, and that the molecules are irreversibly adsorbed onto the substrate. A statistical polymer chain analysis has been...

Nowadays the identification of small RNAs (sRNAs) and characterization of their role within regulatory networks takes a prominent place in deciphering complex bacterial phenotypes. Compared to the study of other components of bacterial cells, this is a relatively new but fast-growing research field. Although reports on new sRNAs appear regularly, some sRNAs are already subject of research for a...

MICA is a major histocompatibility complex-like protein that undergoes a structural transition from disorder to order upon binding its immunoreceptor, NKG2D. We redesigned the disordered region of MICA with RosettaDesign to increase NKG2D binding. Mutations that stabilize this region were expected to increase association kinetics without changing dissociation kinetics, increase affinity of inte...