Abstract Objective: Pregnancy is an immunological paradox where the maternal immune system develops tolerance to semi-allogeneic fetus yet a sensitizing event that detrimental subsequent organ transplantation. Humoral sensitization by pregnancy in WT mice prevents anti-CD154-mediated matched allograft. In contrast, lacking secreted immunoglobulins (mIgM −/−AID −/−; SIgKO) permitted anti-CD154 m...

IL-27 is an important and non-redundant regulator of effector T cell accumulation in non-lymphoid tissues during infection. Using malaria as a model systemic pro-inflammatory infection, we demonstrate that the aberrant accumulation of CD4⁺ T cells in the liver of infected IL27R(-/-) (WSX-1(-/-)) mice is a result of differences in cellular recruitment, rather than changes in T cell proliferation...

This study was designed to find out the therapeutic efficiency of Argaricus bisporus fungi in treatment toxicity caused by fungus Alternaria aborescens, (30) female mice injury experimentally six groups a single dose (0.5)lµ size oral dosing using stomach tube . Results pathological macroscopic and histopathological ability toxic filtarate events infection when an autopsy after (21days) from in...

Introduction Liver cancer is a common tumor of digestive system. Hepatectomy sometimes results in massive hemorrhage, and intraoperative autotransfusion often required. Material methods Methods: In this basic research, the liver rat model was established, visible tissue surgically removed, blood mice recovered. Results The showed that group had highest recurrence metastasis cancer, lowest group...

Background and purpose Heavy alcohol drinking-induced alcoholic fatty liver, steatohepatitis, early-stage liver fibrosis may progress to advanced-stage (AALF)/cirrhosis. The lack of non-invasive imaging techniques for the diagnosising collagenogenesis in activated hepatic stellate cells (HSCs) can lead incurable at early reversible stage. Proline has been known as most abundant amino acid colla...

Inappropriate nutrition and a sedentary lifestyle can lead to obesity, one of the most common risk factors for several chronic diseases. Although regular physical exercise is an efficient approach improve cardiometabolic health, exact cellular processes are still not fully understood. We aimed analyze morphological, gene expression, lipidomic patterns in liver adipose tissues response exercise....

Spring 2013 | Volume 7 Columbia Undergraduate Science Journal 10 Characterizing the Biomechanical and Biochemical Properties of Mouse Uterine Tissue Eli Mondragon*, Kyoko Yoshida, M.S. Kristin Myers, Ph.D Biomedical Engineering Department, Columbia University, New York, NY 10027 Mechanical Engineering Department, Columbia University, New York, NY 10027 Abstract For a successful pregnancy, the u...

Retinoids regulate not only various cell functions including proliferation and differentiation but also glucose and lipid metabolism. After we observed a marked up-regulation of cellular retinol-binding protein-I (CRBP-I) in the liver of hepatitis B virus x antigen (HBx)-transgenic (HBx Tg) mice which are prone to hepatocellular carcinoma (HCC) and fatty liver, we aimed to evaluate retinoid pat...

Based on animal experiments, a switch of the erythropoietin (EPO) production site from the liver in the fetus to the kidneys in the adult has been postulated. To study the switch in humans, we have quantitated EPO mRNA expression in liver, kidney, spleen, and bone marrow of human fetuses and neonates by means of a competitive polymerase chain reaction (PCR). Tissue samples from 66 routine postm...

Campylobacter fetus is a cause of enteritis and invasive extraintestinal disease in humans. In order to develop an animal model of C. fetus infection, outbred ICR SCID mice were orally challenged with a clinical isolate of C. fetus. The stomachs of SCID mice were heavily colonized with C. fetus, and colonization was associated with the development of chronic atrophic gastritis. This lesion was ...