The mechanisms responsible for cytokine-mediated antiviral effects are not fully understood. We approached this problem by studying the outcome of intraocular herpes simplex (HSV) infection in transgenic mice that express interferon gamma in the photoreceptor cells of the retina. These transgenic mice showed selective survival from lethal HSV-2 infection manifested in both eyes, the optic nerve...

Ghrelin has been identified as a multifunctional peptide that potential application for treating Parkinson's disease (PD). The objective of this study was to assess the effects subcutaneous administration low-dose ghrelin via miniosmotic pumps on PD progression. decreased levels total and active in plasma were rescued by mice. Interestingly, did not affect weight gain wild-type mice but improve...

Abstract Irgm1 is a 47kDa IFN-γ inducible GTPase that has been shown to be essential for controlling Mycobacterium tuberculosis (Mtb) infection in mice. It was originally recruited Mtb containing phagosomes infected macrophages where it proposed involved autophagy-mediated clearance of Mtb. However, we have previously discovered autophagy not required control replication. In addition, since rep...

aim : to create an orthotopic hepatoma model with local metastasis monitored with ultrasound could be created as a platform for testing new treatments.   background : hepatoma accounts for 25% of liver tumors in children with poor overall survival. intraabdominal metastasis are present in 35% of patients at time of diagnosis.  we hypothesized that an orthotopic tumor model with local metastasis...

The effect of dietary tyrosine and phenylalanine on survival of adult female C57BL/6 x DBA/2 F, mice bearing i.p. slowgrowing, moderately pigmented and fast-growing, highly pigmented B16 melanoma tumors was studied alone and in com bination with carbidopa-levodopa methyl ester chemotherapy. These studies tested three different diets: a natural product diet containing 1.09% phenylalanine and 0.6...

we have previously shown the adjuvant activity of propranolol (prp) (a beta-adrenergic receptor antagonist) using a vaccine model for salmonella typhimurium. in this study prp was used as an adjuvant in combination with plasmodium  berghei  (p. berghei)  whole blood stage (pwbs) antigens. balb/c mice were immunized three times with a 2-week interval, either pwbs vaccine alone or in combination ...

background: ovarian tissue transplantation is emerging technologies for fertility preservation. in addition, in vitro maturation (ivm) of oocytes retrieved from ovarian tissues may overcome the fertility defects in certain cases. objective: the aim was to evaluate the best site for ovarian tissue transplantation in mice. also, feasibility of ivm of oocytes retrieved from auto grafted ovarian ti...

Most cancer drugs used in a clinical setting are insufficiently effective and safe. This prompts the search for novel substances to fight cancer. The aim of this study was explore effects dihydrobromide 2-(3,4-dihydroxyphenyl)-9-diethylaminoethylimidazo[1,2-a] benzimidazole (RU-185) on growth metastasis experimentally induced transplantable Lewis lung carcinoma (LLC). Fifty-five C57/Bl6 male mi...

Abstract TIGIT has emerged as a critical regulator of phenotype and function in mouse human NK cells with key studies showing upregulation suppresses anti-tumor responses. However, the role promoting survival received less attention. We hypothesized that exerts dual on balancing decreased activation enhanced survival. Our results showed sorted TIGIT+ TIGIT-cell subsets upregulate to near 100%, ...

Natural killer cells are specific innate lymphoid which have therapeutic ability in adoptive cell transferprimarily based on most cancers immunotherapy that has been installed throughout a variety of earlyphase clinical trials. to be used transfer treatments received from diverse resources. These attracted widespread interest as for because their preventive antitumor properties. In order study ...