Oropharyngeal candidiasis (OPC) is among the most common opportunistic infections observed in persons infected with human immunodeficiency virus. A once-daily miconazole 50 mg mucoadhesive buccal tablet (MBT) is a novel delivery system with potent in vitro activity against many Candida species, including some that may be resistant to other azoles. MBT, although more expensive, offers an effecti...

OF DISSERTATION Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Biology for the Graduate School of Arts and Sciences of Northeastern University, March 2008 4 ABSTRACT Fungal pathogens form biofilms that are highly recalcitrant to antimicrobial therapy. We report that biofilms formed by the major human pathogen Candida albicans exhibit biphasic kill...

BACKGROUND Infection with the anthropophilic fungus Trichophyton tonsurans has spread among members of combat sports clubs and has become a serious public health problem in Japan and other countries. Infection usually provokes only a weak inflammatory response, and treatment compliance tends to be poor. OBJECTIVE To evaluate the hairbrush method and the treatment protocol described in the gui...

The effects of several physical and chemical agents on the survival of Trichophyton mentagrophytes arthrospores were investigated. Although arthrospores of this dermatophyte were highly resistant to chilling and freezing, they were extremely susceptible to moderate heat (above 50 degrees C) and desiccation. This high susceptibility could be significantly reduced when they were dried in the pres...

The dimorphic fungus Candida albicans excretes farnesol, which is produced enzymatically from the sterol biosynthetic intermediate farnesyl pyrophosphate. Inhibition of C. albicans by four azole antifungals, fluconazole, ketoconazole, miconazole, and clotrimazole, caused elevated farnesol production (10- to 45-fold). Furthermore, farnesol production occurs in both laboratory strains and clinica...

Fungal endophthalmitis after surgery or trauma is uncommon. 1-7 We are not aware of any report in the literature ofScytalidium dimidiatum (under the name S synanamorph subspecies of Hendersonula toruloidea) causing eye infection.>" This paper reports a severe case of S dimidiatum -endopthalmitis following trauma. Despite intraocular amphotericin B, miconazole, topical natamycin, and extensive s...