To the Editor: I read with interest the case of primary aldosteronism (PA) presented by Chen et al. The clinical course, resolution of hypokalemia and hypertension by right adrenalectomy, and the pathological finding, a cortical microadenoma in the resected adrenal gland, support their diagnosis of aldosterone-producing adenoma of the right adrenal gland. However, I would like to comment about ...

The aim of this study was to investigate the etiologies and clinical manifestations of hyperprolactinemia in a medical center. From May 1999 through October 1999, 140 consecutive patients with hyperprolactinemia were enrolled. Medical records of demographic data, presenting symptoms, departments visited, serum prolactin level, brief history, comprehensive drug history (drug name or classes of d...

Muhammad Burhan Ud din Janjua, Inayat Ullah Khan Department of Neurosurgery, Shifa International Hospital, Islamabad, Pakistan. ABSTRACT Objective To present the local experience of fat graft use for sella closure in case of intraoperative CSF leak to prevent the post operative CSF rhinorrhea. Patient and Methods We retrospectively studied 22 cases operated for pituitary adenomas from 2004 to 2...

OBJECTIVE To describe the work-up and treatment of rare ectopic acromegaly caused by a biopsy-proven somatotroph pituitary adenoma located within the bony intersphenoid septum of a patient with empty sella syndrome (ESS). METHODS We report the presentation, clinical course, diagnostic work-up, and lesion localization and treatment challenges encountered in a 55-year-old patient, with a brief ...

INTRODUCTION Carney complex is an autosomal dominant syndrome with multiple neoplasms in different sites, including myxomas, endocrine tumors and lentigines lesions. To the best of our knowledge, this is the first report of Carney complex presenting with a unilateral adrenal adenoma associated with a pituitary incidentaloma. CASE PRESENTATION A 27-year-old Iranian woman was referred to our en...

A retrospective study was undertaken in 113 patients with surgically proven pituitary adenomas to correlate the frequency, type, and location of computed tomographic (CT) abnormalities with surgical findings. There were 63 prolactin-secreting, 19 growth-hormone-secreting, 12 adrenocorticotropic-hormone-secreting, two thyroid-stimulating-hormone-secreting, and 17 nonfunctioning adenomas. The 51 ...

A 43-year-old woman, previously misdiagnosed as having primary hyperthyroidism and treated with antithyroid drugs, presented to us with overt hyperthyroidism, high levels of thyroid hormones and elevated thyroid-stimulating hormone (TSH). Μagnetic resonance imaging (MRI) revealed a pituitary microadenoma extending suprasellarly. The patient responded favorably to initial treatment with somatost...

Objective To report the evolution of patients with a suggestive clinical scenario and elevated serum insulin-like growth factor-1 (IGF-1), but growth hormone (GH) suppression in the oral glucose tolerance test (OGTT), in whom acromegaly was not initially excluded. Subjects and methods Forty six patients with a suggestive clinical scenario, who had elevated IGF-1 (outside puberty and pregnancy...

We describe two male pubertal cases of constitutionally tall stature (CTS) with an enlarged pituitary gland or pituitary microadenoma. Both patients' basal serum growth hormone (GH) levels were normal. Neither had oversecretion of any other pituitary hormones. However, their serum GH levels were paradoxically increased in response to an intravenous administration of thyrotropin-releasing hormon...

PURPOSE To assess the accuracy of MR in the preoperative identification of corticotropin-secreting pituitary microadenomas. METHODS Twenty-six patients with clinical and biochemical evidence of pituitary-driven Cushing disease in whom MR of the seller region was performed were selected for this study. The MR examinations were retrospectively evaluated by a neuroradiologist who was aware of th...