Several challenges await new assistant professors setting up a neuroscience lab, and obtaining sufficient research help is typically a top priority. A secondary, but no less daunting, challenge is juggling accuracy and reliability with costs and limited start-up funds. These concerns are particularly crucial for those engaging technically sophisticated measurements, such as microdialysis. We ha...

The use of biologics in the therapeutic landscape has increased exponentially since last 3 decades. Nevertheless, patients with central nervous system (CNS) related disorders could not yet benefit from this revolution because blood-brain barrier (BBB) severely hampers entering brain. Considerable effort been put into generating methods to modulate or circumvent BBB for delivery therapeutics CNS...

Anticonvulsant activity of N-(p-aminobenzoyl)-1,2,3,4-tetrahydro-4-methylquinoline (NMQ), a newly synthesized ameltolide analogue, was investigated with regards to efficacy, lethality and neurotoxicity in mice. In vivo microdialysis experiments on freely moving rats were also performed in search for the possible effect of NMQ on cortical amino acid neurotransmitters. Similar to ameltolide, intr...

This series of experiments investigated whether the NMDA receptor antagonist D-2-amino-5phosphonopentanoate (DAP5) could induce impairments of spatial learning across a dose range comparable to its impairment of hippocampal long-term potentiation (LTP) in vivo. Estimations of the extracellular concentration of D-AP5 in hippocampus using microdialysis were also made to compare whether these impa...

ysis sampling in pharmacokinetics research has proven to have many benefits such as clean samples, more frequent samples, conservation of body fluid, and fewer animals per study. In addition, it provides a direct profile of pharmacokinetics within the tissue of interest instead of traditional methods which calculate the tissue concentration indirectly from serial blood samples. Microdialysis sa...

To the Editor: Hyperglycemia, a common feature in critically ill patients, was traditionally perceived as an adequate stress response reflecting the severity of the disease state and was treated only if glycemia exceeded 11–13.5 mmol/L. In recent studies in intensive care patients, we showed that tight glycemic control (TGC) with intensive insulin therapy (IIT) reduced the risk of organ failure...

This series of experiments investigated whether the NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5) could induce impairments of spatial learning across a dose range comparable to its impairment of hippocampal long-term potentiation (LTP) in vivo. Estimations of the extracellular concentration of D-AP5 in hippocampus using microdialysis were also made to compare whether these im...