An array of platinum electrodes [Fig. 1] has been integrated in standard CMOS technology that allows each electrode to be simultaneously used for stimulation and recording. The microelectrode array exhibits a shifted-electrode design for improved electrode stability. The system architecture includes A/D converters for each row and a digital control unit that scans the array and provides a digit...

High frequency oscillations have been proposed as a clinically useful biomarker of seizure generating sites. We used a unique set of human microelectrode array recordings (four patients, 10 seizures), in which propagating seizure wavefronts could be readily identified, to investigate the basis of ictal high frequency activity at the cortical (subdural) surface. Sustained, repetitive transient i...

High frequency oscillations have been proposed as a clinically useful biomarker of seizure generating sites. We used a unique set of human microelectrode array recordings (four patients, 10 seizures), in which propagating seizure wavefronts could be readily identified, to investigate the basis of ictal high frequency activity at the cortical (subdural) surface. Sustained, repetitive transient i...

A manufacturing process has been developed for a microelectrode array that can he used for stimulation of the visual cortex to provide an effective sense of sighf to the blind. The first prototype merges sixteen 316L stainless sfeel electrodes on a 4x4 array. Several arrays can then he assembled together in a mosaic configuration to cover a large portion of the visual area. To reduce brain inju...

A novel silicon-based microelectrode array with oneand two-dimensional variants was developed in the framework of the EUfunded research project NeuroProbes. The electrode array comprises complementary-metal-oxide-semiconductor based integrated circuitry to implement the concept of electronic depth control which is used to select up to 32 recording sites from more than 1000 possible electrode ch...

A device for cell culture is presented that combines MEMS technology and liquid-phase photolithography to create a microfluidic chip that influences and records electrical cellular activity. A photopolymer channel network is formed on top of a multichannel microelectrode array. Preliminary results indicated successful local thermal control within microfluidic channels and control of lamina posi...

PEG-modified diblock copolymer surfaces have been examined for their compatibility with microelectrode array based analytical methods. The use of PEG-modified polymer surfaces on the arrays was initially problematic because the redox couples used in the experiments were adsorbed by the polymer. This led the current measured by cyclic voltammetry for the redox couple to be unstable and increase ...

An impedimetric biosensor platform for bio-affinity assays was developed based on real-time, label-free electrochemical detection performed via direct interface to electronic digital data processing. The sensor array consists of 15 gold microelectrode pairs enclosed in three reaction chambers and bio-functionalized with specific DNA probes. The impedance change caused by specific target analyte...