Dextran sulfate sodium (DSS)-induced murine colitis represents an experimental model for human inflammatory bowel disease. The aim of this study was to screen various inbred strains of mice for genetically determined differences in susceptibility to DSS-induced colitis. Mice of strains C3H/HeJ, C3H/HeJBir, C57BL/6J, DBA/2J, NOD/LtJ, NOD/LtSz- Prkdcscid/Prkdcscid , 129/SvPas, NON/LtJ, and NON.NO...

The Apc(MIN/+) mouse is a well-characterised model of intestinal tumourigenesis in which animals develop macroscopically detectable adenomas. However, most of the adenomas are formed in the small intestine and resolution of events in the colon, the most relevant site for human disease, is limited. Inducing colitis with dextran sodium sulphate (DSS) can selectively enhance the development of les...

This study investigates the changing intellectual structure of the decision support system (DSS) field by means of an empirical assessment of the DSS literature over two successive time periods, 1971-1990 and 1991-1995. A multivariate data analysis tool, cluster analysis, is applied to an author cocitation frequency matrix derived from a large database file of comprehensive DSS literature over ...

Patients with ulcerative colitis (UC) exhibit an increased risk for the development of cancer of the colon and rectum. This association is widely attributed to colonic inflammation. However, the severity of colonic inflammation necessary for the development of dysplasia and/or cancer remains unknown. In this study, we investigated the pattern of cell proliferation in colorectal carcinogenesis i...

BACKGROUND/AIMS The unique role of enzyme 5-lipoxygenase (5-LO) in the production of leukotrienes makes it a therapeutic target for inflammatory bowel disease (IBD). The aim of this study was to evaluate the effects of B-98, a newly synthesized benzoxazole derivatives and a novel 5-LO inhibitor, in a mouse model of IBD induced by dextran sulfate sodium (DSS). METHODS C57BL/6 mice were randoml...

A strong correlation exists between inflammatory bowel disease (IBD) and oxidative stress involving alterations of several key signaling pathways. It is known that methionine promotes reactive oxygen species (ROS) production; we therefore hypothesize that a methionine restriction diet would reduce ROS production, inflammatory responses, and the course of IBD. We generated a murine colitis model...

Inflammation is potential risk factor of various human malignancies. Inflammatory bowel syndromes such as ulcerative colitis are well known as risk factors for colon cancer. Here, we examined enhancing effects of dextran sulfate sodium (DSS)-associated inflammation on X-irradiation induced colonic tumorigenesis in Min and wild-type (WT) mice. Animals were X-irradiated at 1.5 Gy at 5 weeks of ag...

PRECISE ANATOMICAL ANALYSIS OF STENOTIC LESIONS OF THE LEFT VENTRICULAR outflow tract (LVOT) in discrete subaortic membranous stenosis (DSS) and hypertrophic obstructive cardiomyopathy (HOCM) is challenging due to their complex nature (1,2). In the present study, we clarified the difference of the geometry and dynamic change of LVOT area using en face views of the LVOT in 6 patients with DSS an...

In this research, a Decision Support System (“DSS”) was developed, using a combination of various existing models for Integrated Water Management (“IWM”). This DSS is then applied to a small urbanized basin, the Taguri-River basin in Japan. In developing the DSS, different existing dynamic and steady state models were combined. These models include a rainfall-runoff analysis model, two river an...

OBJECTIVES We tested the hypothesis that age is a prognostic factor with respect to long-term accumulation of disability in multiple sclerosis (MS). METHODS Kaplan-Meier analysis and binary logistic regression models determined the effect of age at disease onset, age at onset of progression, and current age on attainment of severe disability levels (Disability Status Scale [DSS] 6-8-10) from ...