background: genome instability is a main cause of chromosomal alterations in both somatic and germ cells when exposed to environmental, physical and chemical genotoxicants. germ cells especially spermatozoa are more vulnerable to suffering from dna damaging agents during spermatogenesis and also more potent in transmitting genome instability to next generation. methods: to investigate the effec...

background: mannitol is present in the ethyol ® (the trade name of amifostine) as an excipient. the mechanism of radioprotection of amifostine is radical scavenging. since mannitol is another known radical scavenger, we studied the probable additive or synergistic effect of mannitol on the effect of amifostine. material and methods: mice were irradiated with co-60 γ -ray in the presence 400mg/k...

To the Editor: I read the research findings of Basu et al. (1) with great interest. However, there are some points which should be discussed. The authors showed that the level of lymphocytes with micronuclei in control (unexposed) persons was extremely low (1.66%). For example, in some European nations it is between 7% and 18% (2-7), and the least is in Turkish subjects—2.8% (8). According to t...

To the Editor: I read the research findings of Basu et al. (1) with great interest. However, there are some points which should be discussed. The authors showed that the level of lymphocytes with micronuclei in control (unexposed) persons was extremely low (1.66%). For example, in some European nations it is between 7% and 18% (2-7), and the least is in Turkish subjects—2.8% (8). According to t...

This study investigated the effectiveness of the liver micronucleus (MN) assay using juvenile mice. Therefore, we analyzed various hepatic cytochrome P450 (CYP)- mediated activities of ethoxyresorufin O-deethylation, pentoxyresorufin O-dealkylation, tolbutamide hydroxylation, bufuralol 1'-hydroxylation, aniline hydroxylation and midazolam 4-hydroxylation by CYP1A, CYP2B, CYP2C, CYP2D, CYP2E and...

the aim of this study was the evaluation of acute genotoxic effect of effluent water of thermo-power plant by means of tradescantia root tips micronucleus test (mn), mitotic index and cell aberrations.   tradescantia , was experimentally treated (for 24 h), with effluent water of thermo-power plant in different dilution ratios (negative control – distilled water; primary untreated effluent wate...

Unrepaired or misrepaired radiation damage in mammalian chromosomes can result in micronucleus formation at the first cell division. This represents loss of genomic information which may cause cell death. To improve our understanding of the mechanism of radiation-induced micronucleus formation, we characterized micronucleus ultrastructure and identified the origin of micronucleus DNA. Immunoflu...

The ICF syndrome is a rare disorder where patients show undercondensation of the heterochromatic blocks of chromosomes 1, 9, and 16 along with variable immunodeficiency. The undercondensation of the heterochromatic block appears to be restricted to a portion of PHA stimulated T cells. Patients with this syndrome also show an increase in micronuclei formation. We have used dual colour FISH to in...

According to WHO over 1 billion people are associated with tobacco smoking and it accounts for approximately 4 – 5 million deaths a year worldwide which is estimated to increase to 10 million by 2030. Tobacco is a known causative agent in numerous cancers one of the major being oral cancer. Buccal mucosal cells are easily accessible and their response to the carcinogenic substances in cigarette...