With the recent interest of protease-activated receptors (PAR) 1 and PAR4 as possible targets for the treatment of thrombotic disorders, we compared the efficacy of protease-activated receptor (PAR)1 and PAR4 in the generation of procoagulant phenotypes on platelet membranes. PAR4-activating peptide (AP)-stimulated platelets promoted thrombin generation in plasma up to 5 minutes earlier than PA...

DOI: 10.1002/admt.201700177 organisms. The manipulation of superparamagnetic microparticles, in particular, has a wide range of applications, including magnetic logic;[13] sorting and trapping of magnetically tagged proteins,[14] cells,[15] and microorganisms;[16] microfluidic mixing;[17] magnetoresistive biosensing;[18] immunoassays;[19] and lab-on-a-tube devices.[20] In principle, the manipul...

Varun Saxena Using a fixed beam with a fundamental Gaussian mode, a gradient force optical trap was used to translate a single cell using a carboxylated polystyrene bead as a handle. Currently, the force with which the optical trap can manipulate an individual cell alone is very weak. In fact, the inadequate nature of the optical trap on living cells has prevented this technique from being usef...

While several recent reports have described the toxicity of water-soluble C60 fullerene nanoparticles, none have reported the toxicity resulting from the inhalation exposures to C60 fullerene nanoparticles or microparticles. To address this knowledge gap, we exposed male rats to C60 fullerene nanoparticles (2.22 mg/m3, 55 nm diameter) and microparticles (2.35 mg/m3, 0.93 microm diameter) for 3 ...

BACKGROUND The endothelial protein C receptor plays an important role within the protein C pathway in regulating coagulation and inflammation. Recently, we described that endothelial protein C receptor can be released in vitro in microparticulate form from primary endothelial cells by exogenous activated protein C. Activated protein C bound to this endothelial protein C receptor retains anticoa...

With the recent interest of protease-activated receptors (PAR) 1 and PAR4 as possible targets for the treatment of thrombotic disorders, we compared the efficacy of protease-activated receptor (PAR)1 and PAR4 in the generation of procoagulant phenotypes on platelet membranes. PAR4-activating peptide (AP)–stimulated platelets promoted thrombin generation in plasma up to 5 minutes earlier than PA...

Yang M, Barak OF, Dujic Z, Madden D, Bhopale VM, Bhullar J, Thom SR. Ascorbic acid supplementation diminishes microparticle elevations and neutrophil activation following SCUBA diving. Am J Physiol Regul Integr Comp Physiol 309: R338–R344, 2015. First published July 1, 2015; doi:10.1152/ajpregu.00155.2015.—Predicated on evidence that diving-related microparticle generation is an oxidative stres...

INTRODUCTION Polymer-based delivery systems offer innovative intra-cavity administration of drugs, with the potential to better target micro-deposits of cancer cells in brain parenchyma beyond the resected cavity. Here we evaluate clinical utility, toxicity and sustained drug release capability of a novel formulation of poly(lactic-co-glycolic acid) (PLGA)/poly(ethylene glycol) (PEG) microparti...