Tolbutamide and gliclazide block the KATP channel Kir6.2/Sur1, causing membrane depolarization and stimulating insulin secretion in pancreatic beta cells. We examined the ability of the EPAC-selective cAMP analog 8-pCPT-29-O-Me-cAMP-AM to potentiate the action of these drugs and the mechanism that might account for it. Insulin secretion stimulated by both 200 mM tolbutamide and 20 mM gliclazide...

Concerns exist about adequacy of vitamin D in pregnant women relative to both maternal and fetal adverse health outcomes. Further contributing to these concerns is the prevalence of inadequate and deficient vitamin D status in pregnant women, which ranges from 5 to 84% globally. Although maternal vitamin D metabolism changes during pregnancy, the mechanisms underlying these changes and the role...

The character of the incoming plate subducting at convergent margins and the processes affecting it as it passes below the shallow forearc may play a major role in the nature and extent of hazardous intraplate seismicity as well as the magnitude of volcanism and the chemistry of lavas produced in the overlying volcanic arc. The fate of incoming sediments and ocean crust and of their associated ...

endothelial cells present in brain are unique and differ from other peripheral tissues in a number of ways, which ensures specific brain endothelial barrier properties. endothelial dysfunction is the earliest event in the initiation of vascular damage caused by inflammation. various micrornas (mirna) have been discovered in different cellular components of the blood bran barrier (bbb). mirnas a...

micrornas are highly conserved small non-coding regulatory rnas that involve in post transcriptional regulating of gene expression during different cellular mechanisms. aberration of mir-218 expression during tumorigenesis of different solid tumors has been reported by numerous studies. in current systematic review article, by using the terms “mir-218” and “cancer” we first searched for english...

Background and Aims: Epicardial adipose tissue, exosomes, miRNAs have important activities in atherosclerosis. The purpose of this study was to establish miRNA expression profiles epicardial tissue-derived exosomes patients with coronary Methods: Biopsies tissue were obtained from without artery disease (CAD, n = 12 NCAD, 12) during elective open-heart surgeries. Tissue incubated DMEM-F12 for 2...