BACKGROUND High-fat diets promote hepatic lipid accumulation. Paradoxically, these diets also induce lipogenic gene expression in rodent liver. Whether high expression of these genes actually results in an increased flux through the de novo lipogenic pathway in vivo has not been demonstrated. METHODOLOGY/PRINCIPAL FINDINGS To interrogate this apparent paradox, we have quantified de novo lipog...

Mitochondrial diseases are a diverse family of genetic disorders caused by mutations affecting mitochondrial proteins encoded in either the nuclear or the mitochondrial genome. By impairing mitochondrial oxidative phosphorylation, they compromise cellular energy production and the downstream consequences in humans are a bewilderingly complex array of signs and symptoms that can affect any of th...

Abstract TTFields are FDA approved for treating patients with GBM. utilize low intensity electric fields intermediate frequency (100-500 kHz) that disrupt cellular processes critical cancer cell viability and tumor progression. have been shown to multiple phases of the cycle including metaphase, anaphase, telophase, resulting in apoptosis. administered through two pairs capacitive arrays placed...

Microplastics are plastic particles less than 5 mm in diameter. These plastics mostly result from degradation of larger plastics. Due to their small size, they often accidentally ingested by sea faunas, particularly the deposit and filter feeders. However, information on ingestion microplastics fauna such as jellyfish is rare. This paper provides evidence jelly fishes (Crambionella orsini) alon...

AIMS Define the impact of age at diagnosis on degenerative mitral regurgitation (MR) prognosis. METHODS AND RESULTS The Mitral regurgitation International DAtabase (MIDA) is a multicentre registry of MR due to flail leaflets including 862 patients (65 ± 12 years) diagnosed by echocardiography. The 498 older patients (≥65 years at diagnosis) were compared with the 364 younger (<65) with regard...

AIMS To determine the frequency, predictors, and outcome implications of pulmonary hypertension (PH) diagnosed by Doppler echocardiography in a large cohort of patients with the homogenous diagnosis of degenerative mitral regurgitation (MR) due to flail leaflets. METHODS AND RESULTS The Mitral Regurgitation International DAtabase (MIDA) is a registry including patients with MR due to flail le...

BACKGROUND Ejection fraction (EF) as a marker of left ventricular (LV) dysfunction and the appropriate thresholds for diagnosing severe or mild/moderate LV dysfunction in mitral regurgitation are doubted and poorly followed in clinical practice. We aimed at assessing the role of EF in a large registry of organic mitral regurgitation to objectively establish thresholds for various degrees of LV ...

Les partícules metàl·liques de mida nanomètrica o Metal NanoParticles (MNP) són objecte de gran interès en la recerca química actual a causa de les seves especials propietats elèctriques, magnètiques i òptiques, entre d’altres, que són diferents de les del material macroscòpic i, a la vegada, diferents de les dels àtoms i les molècules en forma aïllada. No obstant això, les MNP poden ser força ...