Background: To study the histomorphological effects of Mifepristone treatment on rat uterus. Methods: In this experimental study, sixty adult female rats were divided randomly into two groups, comprising of 30 animals in each group. In group A one ml of normal saline was given orally daily for three months while in group B mifepristone was given orally in a dose of 1 mg/kg body weight daily for...

Background: Intrauterine fetal death (IUFD) occurs in 1% of pregnancies and has devastating consequences. Previous methods for inducing labor IUFD involved oxytocin prostaglandins. The combination mifepristone misoprostol is commonly used early first-trimester termination. This study aimed to compare the effectiveness versus alone induction intrauterine death. Methods: A randomized controlled c...

Emergency post-coital contraception (EC) is an effective method of preventing pregnancy when used appropriately. EC has been available since the 1970s, and its availability and use have become widespread. Options for EC are broad and include the copper intrauterine device (IUD) and emergency contraceptive pills such as levonorgestrel, ulipristal acetate, combined oral contraceptive pills (Yuzpe...

Drug therapies are usually contraindicated in specific patient populations where evidence suggests that administration may result in a serious reaction or may seriously and negatively alter the risk benefit of treatment. There are few absolute contraindications to licensed regimens of mifepristone and prostaglandin for termination of pregnancy. However, those that are specified on "summary of p...

OBJECTIVE To review published reports of first-trimester medical abortion regimens that do not include mifepristone. METHODS Reports listed in Pubmed and Medline on prospective and controlled trials of the efficacy of misoprostol, alone or associated with methotrexate, for first-trimester abortion were analyzed if they included more than 100 participants and were published since 1990. RESUL...

Five pregnant beagle bitches were treated with 2.5 mg mifepristone/kg body weight, twice a day, for 4.5 days starting at Day 32 of gestation. Results of fetal ultrasonography and assay of serum progesterone concentrations every 2-4 days were compared to those in 5 control bitches. Mifepristone resulted in a premature (P less than 0.01) termination of pregnancy (36 +/- 1 vs 65 +/- 1 days), witho...