It has been established that microRNAs (miRNAs) play an important role in gene expression by post-transcriptional regulation of messengerRNAs (mRNAs). However, the precise relationships between microRNAs and their target genes in sense of numbers, types and biological relevance remain largely unclear. Dissecting the miRNA-target relationships will render more insights for miRNA targets identifi...

Cardiovascular disease remains the major cause of morbidity and mortality; according to statistics, heart failure, the syndrome consequential to many diseases of the cardiovascular system, is estimated to have a prevalence of 1–2% and an annual incidence of 5–10 per 1,000 in the developed countries and is the leading cause of hospitalization in the population over 50 years of age. Worse so, the...

MicroRNAs (miRNAs) are short RNA molecules (∼22 nt long) that act as gene regulators in many eukaryotes. By binding to complementary strands of messenger RNAs (mRNAs), they induce translational repression or target degradation. Since their discovery in 1993 (Lee et al., 1993), they have received a lot of attention in the research area and some thousands of miRNAs have been reported in the liter...

conclusions according to the liver microrna data of chinese tree shrew, characteristics of the mir-122 and let-7 families further highlight the suitability of tree shrew as the animal model in hcv research. objectives this study aimed to construct a liver microrna (mirna) data of the tree shrew. materials and methods three second filial generation tree shrews were used in this study. total rna ...

Abstract Background Small RNAs (sRNAs) are 20–30 nt regulatory elements which responsible for plant development regulation and participate in many stress responses. Insufficient inorganic phosphate (Pi) concentration triggers responses to balance the internal Pi level. Results In this study, we describe Pi-starvation-responsive small transcriptome changes barley ( Hordeum vulgare L.) using Next...

Sweet sorghum (Sorghum bicolor L) is a C4 plant, and it recently has emerged as model feedstock for biofuel production. MicroRNAs (miRNAs) are known key regulators in different biological processes plant including sugar accumulation. Despite bioinformatics analyses the discovery of miRNAs prediction targets recent years, little information available on expression mature candidate validation the...