OBJECTIVE To describe the clinical cardiac manifestations and temporal evolution of Marfan syndrome in children; to estimate the incidence of annuloaortic ectasia and mitral valve prolapse; and to evaluate tolerability and efficacy of beta-blockers in these patients. METHODS During one year, 21 children with Marfan syndrome underwent serial clinical and echocardiographic examinations. Echocar...

OBJECTIVE To evaluate the cardiovascular findings and clinical follow-up of patients with Williams-Beuren syndrome. METHODS We studied 20 patients (11 males, mean age at diagnosis: 5.9 years old), assessed for cardiovascular abnormalities with electrocardiography and Doppler echocardiography. Fluorescence in situ hybridization (FISH) was used to confirm the diagnosis of the syndrome. RESULT...

Clinical, electrocardiographic, phonocardiographic, and echocardiographic examinations were performed in 100 presumably healthy young females. Treadmill testing and ambulatory electrocardiographic monitoring were performed in a selected group of these subjects. Phonocardiograms, recorded with the subjects supine at rest, after inhalation of amyl nitrite, and in the upright position, revealed a ...

To what extent is prolapse of the mitral valve associated with mitral regurgitation and the risk of infective endocarditis, rupture of the chordae tendineae, and sudden death? Earlier studies used differing definitions and criteria, and reported prevalence of this deformity varied widely, especially between referral and general population studies. Advances in echocardiography have clarified the...

Mitral valve (MV) prolapse (MVP) is characterized by fibromyxomatous changes in themitral leaflet tissue, with superior displacement of one or both leaflets into the left atrium. It is not an uncommon finding on echocardiographic screening, afflicting 2e3% of the general population, though most of them remain asymptomatic [1e3]. MVP can be distinguished into primary (nonsyndromic) and secondary...

osteogenesis imperfecta (oi) as an inherited connective tissue disorder can affect all tissues that contains type i collagen. well-known cardiac complications of this disease such as aortic root dilatation, aortic regurgitation and mitral valve prolapse have been rarely reported in the literature. coronary artery aneurysm is a rare cardiac complication in oi, as reported in a 19 year old female...

OBJECTIVE The aim of this study was to describe the pattern of lesions responsible for commissural prolapse, the techniques of valve repair and their long-term results. METHODS Between 1992 and 2004, 128 mitral valve repairs were consecutively performed for commissural prolapse. There were 86 males and 42 females, the median age was 57.5 years (range 14-84 years). Forty-six percent of patient...

background and aims: ankylosing spondylitis (as) is an idiopathic chronic inflammatory disease mainly involves sacroiliac and axial joints; but it may also have extra-articular involvement. accordingly, this study was designed to determine the frequency of cardiac involvement among patients with ankylosing spondylitis. methods: this study was performed as a descriptive-analytical cross-section...

Introduction: Body mass index (BMI) can affect cardiac morphology; however, the relationship between BMI and valvular heart diseases has not been thoroughly evaluated. This study aimed to determine the relationship between BMI and mitral valve prolapse (MVP) as one of the most common valve diseases worldwide. It can help us to better understand pathophysiology of this common disease. Materials ...

The therapeutic implications of bicuspid aortic valve associations have come under scrutiny in the transcatheter aortic valve implantation era. We evaluate the spectrum of mitral valve disease in patients with bicuspid aortic valves to determine the need for closer echocardiographic scrutiny/follow-up of the mitral valve. A retrospective analysis of echocardiograms done at a referral hospital o...