BACKGROUND This study aimed to examine the quality in oncology registration trials for new drug application (NDA) or supplemental new drug application (sNDA) as extensions of the indications for use in Japan based on Good Clinical Practice (GCP) audit findings. MATERIALS AND METHODS We collected audit reports of on-site GCP inspections for registration trials in 383 NDAs or sNDAs that were re...

We give a sufficient condition for limiting Sobolev and Hardy inequalities to hold on stratified homogeneous groups. In the Euclidean case, this reduces known cancelling necessary condition. obtain in particular endpoint Korn-Sobolev Korn-Hardy

by the method of weight coefficients and techniques of real analysis, ahardy-hilbert-type inequality with a general homogeneous kernel and a bestpossible constant factor is given. the equivalent forms, the operatorexpressions with the norm, the reverses and some particular examples are alsoconsidered.

Consider the second order divergence form elliptic operator L with complex bounded coefficients. In general, the operators related to it (such as Riesz transform or square function) lie beyond the scope of the Calderón-Zygmund theory. They need not be bounded in the classical Hardy, BMO and even some Lp spaces. In this work we generalize the classical approach and develop a theory of Hardy and ...

The Hardy space on the unit ball in C provides examples of a quasi-free, finite rank Hilbert module which contains a pure submodule isometrically isomorphic to the module itself. For n = 1 the submodule has finite codimension. In this note we show that this phenomenon can only occur for modules over domains in C and for finitely-connected domains only for Hardy-like spaces, the bundle shifts. M...

Studies of stem water in red-osier dogwood (Cornus stolonifera Michx.) using nuclear magnetic resonance spectroscopy indicated that most freezing occurs at temperatures above -30 C in cold-hardy and tender stems. Hardy and tender stems had about the same amount of unfrozen water at -40 C (0.28 gram of water per gram dry weight). When hardy stems were slowly cooled below -20 C, the temperature b...

Résumé Dans cet article, on étudie les fonctions maximales de Hardy–Littlewood pour une grande famille de mesures sur les variétés cuspidales. En particulier, on étudie une famille de variétés à croissance exponentielle du volume sur lesquelles la fonction maximale centrée de Hardy–Littlewood est de type faible (1,1), et la fonction maximale non-centrée de Hardy–Littlewood est bornée sur Lp pou...

Let G/H be a compactly causal symmetric space with causal compactification Φ : G/H → Š1, where Š1 is the BergmanŠilov boundary of a tube type domain G1/K1. The Hardy space H2(C) of G/H is the space of holomorphic functions on a domain Ξ(C) ⊂ GC/HC with L-boundary values on G/H. We extend Φ to imbed Ξ(C) into G1/K1, such that Ξ(C) = {z ∈ G1/K1 | ψm(z) = 0}, with ψm explicitly known. We use this ...

We review and extend a recent suggestion that fine-scale localization of a disease-susceptibility locus for a complex disease be done on the basis of deviations from Hardy-Weinberg equilibrium among affected individuals. This deviation is driven by linkage disequilibrium between disease and marker loci in the whole population and requires a heterogeneous genetic basis for the disease. A finding...

In this paper, the authors obtain continuity of a class linear operators on variable anisotropic Hardy--Lorentz spaces. addition, also that dual space Hardy-Lorentz spaces is BMO-type with exponents. This result still new even when exponent function $p(\cdot)$ $p$.