Nanoparticles have displayed considerable promise for safely delivering therapeutic agents with miscellaneous therapeutic properties. Current progress in nanotechnology has put forward, in the last few years, several therapeutic strategies that could be integrated into clinical use by using constructs for molecular diagnosis, disease detection, cytostatic drug delivery, and nanoscale immunother...

Polyvalent carboxylate-terminating near-infrared (NIR) carbocyanine molecular beacons were prepared by homologation of reactive carboxyl groups of the beacon with imino diacetic acid. Their conjugation with unprotected d-(+)-glucosamine gave dendritic arrays of the carbohydrate on an inner NIR chromophore core. In vivo evaluation of the dendritic glucosamine constructs shows enhanced uptake in ...

The Deductive Object Query Language (DOQL) is a rule-based query language designed to provide recursion, aggregates, grouping and virtual collections in the context of an ODMG compliant object database system. This paper provides a description of the constructs supported by DOQL and the algebraic operational semantics induced by DOQL's query translation approach to implementation. The translati...