Ellipticine is a potent antineoplastic agent exhibiting the multimodal mechanism of its action. This article reviews the mechanisms of predominant pharmacological and cytotoxic effects of ellipticine and shows the results of our laboratories indicating a novel mechanism of its action. The prevalent mechanisms of ellipticine antitumor, mutagenic and cytotoxic activities were suggested to be inte...

From the Hamilton Civic Hospitals Research Centre and McMaster University, Hamilton, Ont., Canada. Address reprint requests to Dr. Weitz at the Hamilton Civic Hospitals Research Centre, 711 Concession St., Hamilton, ON L8V 1C3, Canada. ©1997, Massachusetts Medical Society. FTER almost two decades of intensive research, low-molecular-weight heparins have established their niche as an important c...

Portulaca oleracea L., belonging to the Portulacaceae family, is commonly known as purslane in English and Ma-Chi-Xian in Chinese. It is a warm-climate, herbaceous succulent annual plant with a cosmopolitan distribution. It is eaten extensively as a potherb and added in soups and salads around the Mediterranean and tropical Asian countries and has been used as a folk medicine in many countries....

This review describes the key discoveries over the last 15 years that have led to a clearer understanding of the molecular mechanisms by which bisphosphonate drugs inhibit bone resorption. Once released from bone mineral surfaces during bone resorption, these agents accumulate intracellularly in osteoclasts. Simple bisphosphonates such as clodronate are incorporated into non-hydrolysable analog...

Camptothecin (CPT) derivatives have emerged as a promising group of chemotherapeutic agents. The FDA has approved the CPT derivatives topotecan and irinotecan for second line treatment of ovarian cancer and metastatic colorectal cancer, respectively. These and other CPT derivatives have become part of the multi-million dollar industry that is dedicated to finding better chemotherapeutic agents ...

Therapeutic hypothermia (TH) is nowadays one of the most important methods of neuroprotection. The events that occur after an episode of ischemia are multiple and hypothermia can affect the various steps of this cascade. The mechanisms of action of TH are varied and the possible explanation for the benefits of this therapy is probably the multiple mechanisms of action blocking the cascade of is...

PURPOSE Bisphosphonates are currently the most important class of antiresorptive agents used in the treatment of metabolic bone diseases, including tumor-associated osteolysis and hypercalcemia. These compounds have high affinity for calcium ions and therefore target bone mineral, where they are internalized by bone-resorbing osteoclasts and inhibit osteoclast function. EXPERIMENTAL DESIGN Th...

The review article is devoted to the history of creation, biological effects and clinical application entomological drug Adenoprosin. data experimental studies are presented, indicating a high activity drug, mechanisms its therapeutic action described. pharmacological Adenoprosin were analyzed, which ensure efficacy good tolerability. pathogenetic validity appointment in patients with chronic p...

background: breast cancer is the most common cancer in women worldwide. recently, natural remedies such as naringenin (nar) - a kind of flavonoids which can be found in grapefruits, oranges, and tomatoes - seem to be interesting. they play a useful role in treatment and chemoprevention because of having pleiotropic molecular mechanisms of action on breast cancer cells. methods: we performed a p...