Objectives. Determine outcome of the 2005 appropriateness use criteria (AUC) for SPECT in a diverse population of patients and physicians. Background. AUC for SPECT were the first cardiology document to identify 52 clinical indications for imaging, 49 of them for stress SPECT. AUC have been proposed as cornerstone of responsible use of perfusion imaging. Methods. 585 consecutive patients underg...

UNLABELLED BACKGROUND Unspecific pain of the hand/wrist is a diagnostic challenge. Radiographs and planar bone scan are useful diagnostic tools in patients with unspecific wrist pain. Both modalities are deficient, either by not presenting metabolic disorders or due to inadequate anatomical resolution. Single photon emission computed tomography/computed tomography (SPECT/CT) claims to fuse b...

metastatic survey of the patients with known primary malignancies with bone scan is one of the most common studies in nuclear medicine. unfortunately the conventional planar bone scan has a very low specificity for differentiating benign from malignant lesions especially in the spinal column. in this study, we compared the specificity of spect imaging and conventional planar bone scan. we studi...

This study was undertaken to examine the ability of SPECT in differentiation of a pulmonary lesion suspecions of lung cancr. A total of 170 patients with suspected lung cancer were studied. A dose of Tl-201 chloride {148-296 MBq) was injected intravenously and tomographic early and delayed scans were obtained at 15 miniutes and 3 hours post injection, respectively. Delayed Tl-201 SPECT vi...

UNLABELLED We prospectively evaluated the contribution of 99mTc-HMPAO SPECT in patients who have sustained acute, mild or moderate head trauma. METHODS Forty-two patients formed the first subgroup of moderate trauma (ModTr) and 25 patients formed the second subgroup of mild trauma (MilTr). All 67 patients underwent an initial SPECT (Tinit) within 4 wk after a closed cranial trauma. After a me...

AIMS To determine in a multicentre, multivendor trial the diagnostic performance for perfusion-cardiac magnetic resonance (perfusion-CMR) in comparison with coronary X-ray angiography (CXA) and single-photon emission computed tomography (SPECT). METHODS AND RESULTS Of 241 eligible patients from 18 centres, 234 were randomly dosed with 0.01, 0.025, 0.05, 0.075, or 0.1 mmol/kg Gd-DTPA-BMA (Omni...

Bone metastases are common, especially in more prevalent malignancies such as breast and prostate cancer. They cause significant morbidity draw on health-care resources. Molecular hybrid imaging techniques, including SPECT/CT, PET/CT, whole-body MRI with diffusion-weighted imaging, have improved diagnostic accuracy staging the skeleton compared previous standard methods, allowing earlier tailor...

Oligonucleotides radiolabeled with isotopes emitting γ-rays (for SPECT imaging) or positrons (for PET imaging) can be useful for targeting messenger RNA (mRNA) thereby serving as non-invasive imaging tools for detection of gene expression in vivo (antisense imaging). Radiolabeled oligonucleotides may also be used for monitoring their in vivo fate, thereby helping us better understand the barrie...

The pathophysiology of neurodegenerative diseases (ND) such as Alzheimer's disease (AD) and Parkinson's disease (PD) has not yet been completely elucidated. However, in the past few years, there have been great knowledge advances about intra-and extracellular proteins that may display impaired function or expression in AD, PD and other ND, such as amyloid beta (Aβ), α-synuclein, tau protein and...

Neurology 2012;78:688–689 The Food and Drug Administration (FDA) recently approved [I]ioflupane ([I]-fluoropropyl CIT), a dopamine transporter (DAT) radioligand, for SPECT to “assist in the evaluation of adult patients with suspected parkinsonian syndromes (PS).”1 This permits physicians to prescribe [I]ioflupane SPECT scans as part of clinical practice. Advertisements encourage clinicians to o...