ononuclear phagocytes can fuse to form osteoclasts or multinuclear giant cells. The latter are hallmarks of Crohn’s disease, granulomas, tumors, and fungal and HIV infections. Though the precise function of these syncytia remains unclear, Takeda et al. (page 945) now provide important new insights into phagocyte fusion, suggesting that the process may differ considerably from other types of cel...

ononuclear phagocytes can fuse to form osteoclasts or multinuclear giant cells. The latter are hallmarks of Crohn’s disease, granulomas, tumors, and fungal and HIV infections. Though the precise function of these syncytia remains unclear, Takeda et al. (page 945) now provide important new insights into phagocyte fusion, suggesting that the process may differ considerably from other types of cel...

BACKGROUND The words 'infection' and 'inflammation' lack specific definitions. Here, such words are not defined. Instead, the ability to visualize host-microbial interactions was explored. METHODS Leukocyte differential counts and four bacterial species (Staphylococcus aureus, Streptococcus dysgalactiae, Staphylococcus chromogenes, and Escherichia coli) were determined or isolated in a cross-...

Leishmaniasis is a vector-borne zoonotic disease caused by protozoan parasites of the genus Leishmania, which are responsible for numerous clinical manifestations, such as cutaneous, visceral, and mucocutaneous leishmaniasis, depending on the site of infection for particular species. These complexities threaten 350 million people in 98 countries worldwide. Amastigotes living within macrophage p...

ononuclear phagocytes can fuse to form osteoclasts or multinuclear giant cells. The latter are hallmarks of Crohn’s disease, granulomas, tumors, and fungal and HIV infections. Though the precise function of these syncytia remains unclear, Takeda et al. (page 945) now provide important new insights into phagocyte fusion, suggesting that the process may differ considerably from other types of cel...

gammadelta T cells commonly associate with mucosal and epithelial sites, fulfilling a variety of immunoregulatory functions. While lung gammadelta T cells have well-characterized pro-inflammatory activity, their potential role in the resolution of lung inflammation has yet to be explored in any detail. Indeed, given the importance of minimizing inflammation, the cellular mechanisms driving the ...