The YFL ribozyme is an artificial ligase ribozyme isolated by a 'design and selection' strategy, in which a modular catalytic unit was generated on a rationally designed modular scaffold RNA. This ligase ribozyme has a versatile catalytic unit that accepts not only beta-nicotinamide mononucleotide (beta-NMN) but also inorganic pyrophosphate as leaving groups for template-dependent RNA ligation....

Here, we prove that there is no perfect number of the form Fmn/Fm, where Fk is the kth Fibonacci number.

Nicotinamide mononucleotide (NMN) is an essential precursor of nicotinamide adenine dinucleotide (NAD+), which widely applied in the pharmaceutical and biotech industries. The biosynthesis NMN currently attracting much attention because it has non-toxic reaction conditions low amounts isomers, whereas chemical synthesis yields not environmentally friendly. This review systematically describes t...