Background and Aims: The therapeutic effects of the olibanum, the resin of Boswellia serrata (B. serrata) from the Burseraceae family in inflammatory disease have been reported. There are more than 200 active ingredients in this resin, including Boswellic acid. It is proposed that aqueous extract of B. serrata can improve memory impairment induced by cerebral inflammation result in the adminis...

The effect of a new conjugate hydroxybenzoic acid with glycine on sensory-motor and cognitive impairments in experimental animals chronic cerebrovascular insufficiency (CCI) was studied. CCI modeled rats by stenosis thelumen the carotid arteries 60 %. 40 days after operation, groups were formed test compound administered for 14 days. Citicoline used as reference drug, saline placebo. After trea...

BACKGROUND Panax ginseng root is used in traditional oriental medicine for human health. Its main active components such as saponins and polysaccharides have been widely evaluated for treating diseases, but secondary active components such as oligosaccharides have been rarely studied. This study aimed to assess the impact of water-soluble ginseng oligosaccharides (WGOS), which were isolated fro...

Lurcher mutant mice represent a model of genetically determined olivocerebellar degeneration. In the C3H strain there is also hereditary retinal degeneration. The aim of this work was to assess, whether the retinal degeneration influences spatial orientation and results of the spatial learning tasks. Two experiments in the Morris water maze were arranged. First, mice learned to find a platform ...

Background: The effect of ovariectomy and accompanying sudden loss of circulating gonad hormones on spatial learning performance in the young adult rats was examined. We hypothesized that spatial learning and memory in a considerable number of women who undergo a surgical menopause and estrogen deprivation before their natural menopause be impaired. Methods: In this study, we used 26 Wistar ra...

In the current investigation rhizome of Zingiber officinale and leaf Ocimum sanctum were extracted using ethanol-water (70:30) anti-amnesic potential combined extracts was evaluated in experimental model. The extraction yield hydroalcoholic mixture found to be 10.4 % for 17.7 sanctum. Preliminary phytochemical analysis suggested presence alkaloids, saponin glycosides, phenolics, terpenoids, fla...