Spasticity is commonly observed after chronic spinal cord injury (SCI) and many other central nervous system disorders (e.g., multiple sclerosis, stroke). SCI-induced spasticity has been associated with motoneuron hyperexcitability partly due to enhanced activation of intrinsic persistent inward currents (PICs). Disrupted spinal inhibitory mechanisms also have been implicated. Altered inhibitio...

Salenius, Stephan, Karin Portin, Matti Kajola, Riitta Salmelin, synaptic currents flowing mainly in the fissural cortex. It and Riitta Hari. Cortical control of human motoneuron firing allows noninvasive monitoring of cortical activity with a during isometric contraction. J. Neurophysiol. 77: 3401–3405, reasonable spatial accuracy while maintaining an excellent 1997. We recorded whole scalp mag...

Our previous studies have shown that median and ulnar nerve lesion induced calbindin (CB) immunoreactivity in some injured motoneurons in developing rats. Motoneuron death induced by sciatic nerve transection in neonatal rats has been related to induction of neuronal isoform of nitric oxide synthase (nNOS). The present study investigated whether expression of CB and nicotinomid adenin dinucleot...

1 Innovations in motoneuron synchrony drive rapid temporal modulations in 2 vertebrate acoustic signaling 3 4 Running head: 5 Motoneuron synchrony 6 7 Authors: 8 Boris P. Chagnaud, Michele C. Zee, Robert Baker and Andrew H. Bass 9 Department of Neurobiology and Behavior, Cornell University, Ithaca, NY 1

Embryos of Xenopus laevis were continually immobilized by immersion in solutions of either chloretone or lidocaine, from the late neural-fold stage to the approximate time of hatching. Such treatment has been shown to result in only transient quantitative effects on swimming behavior. Chronic immobilization was without either immediate or long-term effect on the ventral root output exhibited du...

The Effects of Subhypnotic Doses of Ethanol on Regional Catecholamine Turnover. N. G. BACOPOULOS, R. K. BHATNAGAR AND L. S. VAN ORDEN III 1 Effect of General Anesthetics on Handlingand Decapitation-induced Increases in Sympathoadrenal Discharge. MICHAEL F. ROIZEN, JONATHAN Moss, DAVID P. HENRY, VIRGINIA WEISE AND IRWIN J. KOPIN 11 The Effect of Serotonin Precursors on aand y-Motoneuron Activity...

This paper compares the activity of hindlimb motor units from muscles mainly composed of fast-twitch muscle fibers (medial and lateral gastrocnemius: MG/LG, tibialis anterior: TA) to motor units from a muscle mainly composed of slow-twitch muscle fibers (soleus: SOL) during unrestrained walking in the conscious rat. Several differences in the activation profiles of motor units from these two gr...

Proper function of the motor unit is dependent upon the correct development of dendrites and axons. The infant/childhood onset motoneuron disease spinal muscular atrophy (SMA), caused by low levels of the survival motor neuron (SMN) protein, is characterized by muscle denervation and paralysis. Although different SMA models have shown neuromuscular junction defects and/or motor axon defects, a ...