Since the published MS-GFDB did not support variable PTMs at the time that this research was carried out, both MS-GFDB and PEAKS DB were run without specifying any variable PTMs. The other parameters, including the fixed PTMs, remained the same as described in the results section. The results are shown in Figure S2 for CID and Figure S3 for ETD datasets, respectively. Note that the removal of t...

An image may be decomposed as a difference between an image of peaks and an image of wells. Applying a morphological operator to these two components before reconstructing a final image produces interesting filters for grey tone or binary images. This decomposition depends upon the point of view from where the image is considered.

The theory of moving boundary electrophoresis and ultracentrifugation of associating-dissociating and two-component isomerizing systems seems to be rather well understood (1-12). However, until now little was known about the behavior expected of systems in which reversible changes in the electrophoretic mobility of a macromolecular ion are mediated by binding of small uncharged molecules such a...

Smoothing or filtering of data is first preprocessing step for noise suppression in many applications involving data analysis. Moving average is the most popular method of smoothing the data, generalization of this led to the development of Savitzky-Golay filter. Many window smoothing methods were developed by convolving the data with different window functions for different applications; most ...

Non-steady-state processes in capillary electrophoresis can be estimated by applying a steady-state mathematical model. Calculations with a steady-state model indicate that in capillary electrophoresis, moving boundary zones can originate from discontinuities in the concentration of the co-ions and/or the pH of the background electrolyte. Calculations showed that cationic moving boundaries with...

The aim of this paper is to develop a rapid, and highly sensitive quantitative HPLC fingerprint method with multiple indicators by using the Compound Chinese Medicine Wuwei Changyanning granule and 5 herbs in the prescription. The quantitative fingerprint chromatogram with multiple indicators was investigated. ⅰ)6 compositions included rutin, gallic acid, chlorogenic acid, atractylenolideⅠ, pac...

This paper introduces a Moving Finite Elements Method (MFEM) based on cubic Hermite polynomial local approximations to handle Population Balance Equations (PBE) modeling breakage phenomena. The adequacy and performance of the MFEM framework are tested in two case studies involving breakage: a benchmark problem with known analytical solution and the hydrolysis of starch. Both examples emphasize ...

We present a vortex particle method coupled with a penalization technique to simulate single and multiple swimmers in an incompressible, viscous flow in two and three dimensions. The proposed algorithm can handle arbitrarily deforming bodies and their corresponding non-divergence free deformation velocity fields. The method is validated on a number of benchmark problems with stationary and movi...

Vibration Analysis Tests (VAT) and Acoustic Emission tests (AE) are used in several industrial applications. Many of them perform analysis in the frequency domain. Peaks in the power density spectrum hold relevant information about acoustic events. In this paper we propose a novel method for feature extraction of vibration samples by analyzing the shape of their auto power spectrum density func...

The usefulness of Fourier analyses as a tool for determining key parameters of cancellous bone structure is investigated. The autocorrelation function is used to determine measures of preferred orientation of trabeculae and anisotropy. Peaks in the power spectrum are used to determine average trabecular strut spacing. Good agreement and high correlations were observed when these frequency domai...