نتایج جستجو برای: msh

تعداد نتایج: 1552  

Journal: :Genes & development 1998
M M Ollmann M L Lamoreux B D Wilson G S Barsh

Agouti protein and Agouti-related protein (Agrp) are paracrine-signaling molecules that normally regulate pigmentation and body weight, respectively. These proteins antagonize the effects of alpha-melanocyte-stimulating hormone (alpha-MSH) and other melanocortins, and several alternatives have been proposed to explain their biochemical mechanisms of action. We have used a sensitive bioassay bas...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2013
Janell Richardson Maureen T Cruz Usnish Majumdar Amanda Lewin Kathryn A Kingsbury Ghazaul Dezfuli Stefano Vicini Joseph G Verbalis Kenneth L Dretchen Richard A Gillis Niaz Sahibzada

Activation of melanocortin 4 receptors (MC4-Rs) in brain nuclei associated with food intake profoundly influences consummatory behavior. Of these nuclei, the dorsal motor vagal nucleus (DMV), which has a dense concentration of MC4-Rs, is an important regulator of gastric tone and motility. Hence, the present study sought to examine the role of MC4-Rs in this nucleus on these activities. Using a...

2008
Thomas Brzoska Thomas A. Luger Christian Maaser Christoph Abels Markus Böhm

-MSH is a tridecapeptide derived from proopiomelanocortin. Many studies over the last few years have provided evidence that -MSH has potent protective and antiinflammatory effects. These effects can be elicited via centrally expressed melanocortin receptors that orchestrate descending neurogenic antiinflammatory pathways. -MSH can also exert antiinflammatory and protective effects on cells of t...

2008
G. Consolini Z. Nemecek A. Skalsky

593 The region downstream of a supercritical collisionless shock, the magnetosheath (MSH), is known to be in a highly disturbed turbulent state [1–3]. The undisturbed solar wind (SW) streams with supermagnetosonic velocity V > c ms at a magnetosonic Mach number up to M ms ~ 15. At the Earth’s bow shock (BS), the SW decelerates to Mach numbers M ms < 1, thermalizes, and, when entering the MSH, i...

Journal: :Molecular cell 2005
Jingjing Jiang Lu Bai Jennifer A Surtees Zekeriyya Gemici Michelle D Wang Eric Alani

Mismatch repair (MMR) is initiated by MutS family proteins (MSH) that recognize DNA mismatches and recruit downstream repair factors. We used a single-molecule DNA-unzipping assay to probe interactions between S. cerevisiae MSH2-MSH6 and a variety of DNA mismatch substrates. This work revealed a high-specificity binding state of MSH proteins for mismatch DNA that was not observed in bulk assays...

Journal: :Cell reports 2016
Vikram Saini Bridgette M Cumming Loni Guidry Dirk A Lamprecht John H Adamson Vineel P Reddy Krishna C Chinta James H Mazorodze Joel N Glasgow Melissa Richard-Greenblatt Anaximandro Gomez-Velasco Horacio Bach Yossef Av-Gay Hyungjin Eoh Kyu Rhee Adrie J C Steyn

The mechanisms by which Mycobacterium tuberculosis (Mtb) maintains metabolic equilibrium to survive during infection and upon exposure to antimycobacterial drugs are poorly characterized. Ergothioneine (EGT) and mycothiol (MSH) are the major redox buffers present in Mtb, but the contribution of EGT to Mtb redox homeostasis and virulence remains unknown. We report that Mtb WhiB3, a 4Fe-4S redox ...

Melanocortin-1 (MC1) receptor is an attractive melanoma-specific target for the development of α-MSH peptide based imaging and therapeutic agents. In this work a new lactam bridge α-MSH analogue was synthesized and radiolabeled with 99mTc via HYNIC chelator and tricine as co-ligand. Also, stability in human serum, receptor bound internalization and tissue biodistribution in tumor bearing nude m...

Journal: :General and comparative endocrinology 2013
Kanta Mizusawa Yuki Kobayashi Takeshi Yamanome Yumiko Saito Akiyoshi Takahashi

In teleosts, as their names suggest, the main target cells of melanocyte-stimulating hormone (MSH) and melanin-concentrating hormone (MCH) are the chromatophores in the skin, where these peptide hormones play opposing roles in regulating pigment migration. These effects are obvious especially when their activities are examined in vitro. On the contrary, while MCH also exhibits activity in vivo,...

2017
Jerry Wan Fuquan Lin Wei Zhang Aie Xu Joseph DeGiorgis Hongguang Lu Yinsheng Wan

Vitiligo is a skin depigmentation disorder with an increasing prevalence. Among recognized mechanisms is the oxidative stress that affects melanocytes which are responsible for skin pigmentation. Studies have shown that high concentration of hydrogen peroxide, or H2O2, induces apoptotic activities. Few studies have been done with lower doses of H2O2. Using human skin melanocytes, we investigate...

2016
Yan Zhang Qin Liu Ning Yang Xuegang Zhang

Postsurgical adhesion formation is the most common complication in abdominal and pelvic surgery. Adhesiolysis is the most commonly applied treatment for adhesion formation but is often followed by adhesion reformation. Therefore, an efficient strategy should be adopted to solve these problems. This study aimed to explore whether hyaluronic acid and oxidized regenerated cellulose (ORC) could pre...

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