نتایج جستجو برای: mtb
تعداد نتایج: 3669 فیلتر نتایج به سال:
The exact role of CD8(+) T cells during Mycobacterium tuberculosis (Mtb) infection has been heavily debated, yet it is generally accepted that CD8(+) T cells contribute to protection against Mtb. In this study, however, we show that the Mtb-susceptible CBA/J mouse strain accumulates large numbers of CD8(+) T cells in the lung as infection progresses, and that these cells display a dysfunctional...
OBJECTIVE To clone, express, and characterize Mycobacterium tuberculosis (Mtb) ClpP2, and evaluated the potential usage of ClpP2 in clinical diagnosis of tuberculosis. METHODS Mtb ClpP2 was cloned into recombinant plasmid pET32a (+) and transformed into E. coli BL21 (DE3). SDS-PAGE and Western blot analysis were performed to detect the expression of the recombinant protein. The immunogenicity...
BACKGROUND In pulmonary Mycobacterium tuberculosis (Mtb) infection, immune responses are delayed compared to other respiratory infections, so that antigen-specific cells are not detected in the lungs earlier than day 14. Even after parenteral immunization with Bacille Calmette Guerin (BCG) or a subunit vaccine, the immune response after Mtb challenge is only slightly accelerated and the kinetic...
In this study, we developed a mouse model of type 2 diabetes mellitus (T2DM) using streptozotocin and nicotinamide and identified factors that increase susceptibility of T2DM mice to infection by Mycobacterium tuberculosis (Mtb). All Mtb-infected T2DM mice and 40% of uninfected T2DM mice died within 10 months, whereas all control mice survived. In Mtb-infected mice, T2DM increased the bacterial...
Pyroptosis is a host immune strategy to defend against Mycobacterium tuberculosis (Mtb) infection. S100A4, calcium-binding protein that plays an important role in promoting cancer progression as well the pathophysiological development of various non-tumor diseases, has not been explored Mtb-infected hosts. In this study, transcriptome analysis peripheral blood patients with pulmonary (PTB) reve...
یکی از اصول اساسی حسابداری محافظه کاری می باشد و به دلیل محافظت از حقوق بستانکاران در مقابل سهامداران و همچنین سهامداران در مقابل مدیران اهمیت فراوانی در گزارشگری مالی دارد. در سالهای اخیر تحقیقات زیادی در این زمینه در سراسر جهان صورت گرفته است. در این تحقیقات نیاز به معیاری برای سنجش محافظه کاری ضروری است. در این تحقیق تلاش می شود تا به معرفی عدم تقارن زمانی سود و نسبت ارزش بازار به ارزش دفتری...
This work addresses the characterization and control of Magnetotactic Bacterium (MTB) which can be considered as a biological microrobot. Magnetic dipole moment of the MTB and response to a field-with-alternating-direction are characterized. First, the magnetic dipole moment is characterized using four techniques, i.e., Transmission Electron Microscopy images, flip-time, rotating-field and u-tu...
Despite considerable research effort, the molecular mechanisms of Mycobacterium tuberculosis (Mtb) virulence remain unclear. Cholesterol oxidase (ChoD), an extracellular enzyme capable of converting cholesterol to its 3-keto-4-ene derivative, cholestenone, has been proposed to play a role in the virulence of Mtb. Here, we verified the hypothesis that ChoD is capable of modifying the bactericida...
RATIONALE Biomarkers associated with response to therapy in tuberculosis could have broad clinical utility. We postulated that the frequency of Mycobacterium tuberculosis (Mtb) specific CD8(+) T cells, by virtue of detecting intracellular infection, could be a surrogate marker of response to therapy and would decrease during effective antituberculosis treatment. OBJECTIVES We sought to determ...
سابقه و هدف: سل به عنوان دومین علت مرگ و میر ناشی از عفونت شناخته شده است. روش های مولکولی مانند pcr، تکنیک های مناسبی برای شناسایی مایکوباکتریوم توبرکیلوسیس (mtb) هستند. بروز نتایج متفاوت در آزمایشگاه های مختلف، از معایب این تکنیک مولکولی است. این مطالعه با هدف طراحی، ساخت و کاربرد کنترل داخلی در روش pcr به منظور تشخیص mtb انجام شد. مواد و روش ها: به منظور ساخت کنترل داخلی ویژه mtb ، ابتدا پر...
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