The pathology of 21 cases of muco-epidermoid carcinoma of the anal canal is described. These tumours are defined as squamous or transitional cell carcinomas containing areas which secrete mucin of undoubted epithelial origin within the clumps of tumour cells. They are found in that part of the anal canal just above the dentate line where the epithelium is variable in type and represents an embr...

Resumo Apesar dos grandes investimentos, os métodos artificiais de planejamento familiar ainda apresentam limitações. Desde a década 1950, cientistas trabalham para desenvolver um método natural confiável. Este artigo revisa literatura sobre o Método Ovulação Billings, apontando sua lógica, eficácia, seus benefícios, desafios e suas regras. Trata-se natural, embasado em mais cinquenta anos pesq...

Multiciliated cells of the airways, brain ventricles, and female reproductive tract provide the motive force for mucociliary clearance, cerebrospinal fluid circulation, and ovum transport. Despite their clear importance to human biology and health, the molecular mechanisms underlying multiciliated cell differentiation are poorly understood. Prior studies implicate the distal appendage/transitio...

BACKGROUND T2R bitter taste receptors play a crucial role in sinonasal innate immunity by upregulating mucociliary clearance and nitric oxide (NO) production in response to bitter gram-negative quorum-sensing molecules in the airway surface liquid. Previous studies showed that phytochemical flavonoid metabolites, known as anthocyanidins, taste bitter and have antibacterial effects. Our objectiv...

PURPOSE To determine whether trabecular tissue in vivo and cultured trabecular cells have the messenger RNA transcript for transforming growth factor-beta 1 (TGF-beta 1), and to examine whether these cells synthesize and secrete TGF-beta 1 in vitro. METHODS Total RNA was isolated from the trabecular meshwork, iris, and ciliary body freshly excised from porcine eyes as well as from cultured tr...

Most airway mucus is produced by submucosal glands in response to neural signals. Gland mucus traps microbes, inhibits their replication, and clears them from the airways. In cystic fibrosis mucus clearance is compromised, allowing pathogens to persist in static mucus. These trigger an influx of inflammatory cells, but optimal effectiveness of inflammation, and especially its resolution, also r...

Cilia and flagella are formed around an evolutionary conserved microtubule-based axoneme required for fluid mucus clearance, tissue homeostasis, cell differentiation movement. The formation maintenance of cilia require bidirectional transit proteins along the axonemal microtubules, a process called intraflagellar transport (IFT). In humans, IFT defects contribute to large group systemic disease...

objective(s): occlusal trauma is one of the most common forms of oral biting dysfunction. long-term occlusal trauma could weaken the stomatognathic system; especially damage one’s masticatory muscle. through using the rat model, this study investigated the trophic effect of ciliary neurotrophic factor (cntf) on injured masseter muscle. materials and methods: male wistar rats (n=36) were randoml...