Avermectin inhibits Mucor miehei and Artemia salina chitin synthesis and to a degree DNA synthesis in the former. The antibiotic interferes with chitin turnover in brine shrimp and inhibits Streptomyces antibioticus chitinase activity in vitro. In light of the proposed mode of action of avermectin and the anomolies in the literature, it is proposed that avermectin can kill susceptible organisms...

Methanol extracts of whole body (Melampus ceylonicus), blood (Anadara rhombea) and hepatopancreas (Sepiella inermis) were screened for antifungal and cytotoxic activity. Blood of A. rhombea and hepatopancreas of S. inermis strongly inhibited Candida albicans, Mucor racemosus and Penicillium expansum. A. rhombea appear to exert strong cytotoxic activity against vertebrate erythrocytes. The bacte...