Macromomycin (MCR) is a polypeptide antimuor antibiotic isolated from the culture broth of Streptomyces macromomyceticus. Antitumor activities of MCR were examined against three different tumor system, i.e., EHRLICH ascites carcinoma, L1210 leukemia and LEWIS lung carcinoma. Daily intraperitoneal treatment with MCR for 5 days showed a strong inhibition against EHRLICH ascites carcinoma. Both si...

Occluding cell-cell junctions in epithelia form physical barriers that separate different membrane domains, restrict paracellular diffusion and prevent pathogens from spreading across tissues. In invertebrates, these functions are provided by septate junctions (SJs), the functional equivalent of vertebrate tight junctions. How the diverse functions of SJs are integrated and modulated in a multi...

OBJECTIVES The objective of this study was to assess the presence of mcr-1 in Shigella sonnei isolated in Vietnam. METHODS WGS data were analysed for the presence of the mcr-1 gene sequence. The association of mcr-1 with a plasmid was assessed by PCR and by conjugation. RESULTS Through genome sequencing we identified a plasmid-associated inactive form of mcr-1 in a 2008 Vietnamese isolate o...

The emergence of the plasmid-mediated mcr colistin resistance gene in the community poses a potential threat for treatment of patients, especially when hospitalized. The aim of this study was to determine the prevalence of all currently known mcr mediated colistin resistance gene in fecal samples of patients attending a tertiary care hospital. From November 2014 until July 2015, fecal samples o...

Mechanochemically responsive (MCR) polymers have been designed to possess unconventional properties such as changing colors, self-healing, and releasing catalysts under deformation. These properties of MCR polymers stem from a class of molecules, referred to as mechanophores, whose chemical reactions can be controlled by mechanical forces. Although extensive studies have been devoted to the syn...

The free chromophores (chr) extracted from macromomycin (MCR) and auromomycin (AUR) showed different IR spectra in KBr tablets and different CD spectra in ethanol or methanol solution. Chr-MCR contained a greater amount of alkyl moieties than chr-AUR as shown by much stronger IR absorbance at 2960 cm-1. The IR spectra of MCR, AUR and their apo-proteins (apo) in D2O showed that major parts of th...

Methyl-coenzyme M reductase (MCR) is the key enzyme of methanogenesis and anaerobic methane oxidation. The activity of MCR is dependent on the unique nickel-containing tetrapyrrole known as coenzyme F430. We used comparative genomics to identify the coenzyme F430 biosynthesis (cfb) genes and characterized the encoded enzymes from Methanosarcina acetivorans C2A. The pathway involves nickelochela...

microwave-assisted three component cyclocondensation reactions of aldehydes, amides and dienophiles in the presence of acetic anhydride and para-toluenesulfonic acid as a catalyst to afford the highly substituted cyclohexene derivatives, in relatively good yields after several minutes are reported.

surface. MCR is unique in that it apparently inhibits DNA synthesis while binding to the plasma membrane (12, 13). This mechanism of action requires that the binding of MCR to the cell surface freezes on modifies the moleof the mom bnane in mediating cellular metabolism. Kunimotoetal. (13) hypothesize that the interaction between MCR and tumor cells is analogous to the interactions between bact...

A highly practical and efficient preparation of 3,4-Dihydropyrimidin-2(1H)-one derivatives was developed via an efficient and simple nanocatalyst and promoted multi-component reaction of ethyl acetoacetate, aromatic aldehyde, and urea in the presence of a catalytic amount of (CTA)3[SiW12]-Li+-MMT under solvent-free conditions. In comparison to the conve...