The mainstay of clinical antineoplastic chemotherapy is multiagent combinations, most of which were developed empirically. Because of the desire to speed research and decrease costs, there is increasing interest in moving new drugs into clinical trials in potentially active combinations based on preclinical testing data. Different mathematical models have been proposed for evaluating drug inter...

Normative multiagent systems as a research area can be defined as the intersection of normative systems and multiagent systems. Since the use of norms is a key element of human social intelligence, norms may be essential too for artificial agents that collaborate with humans, or that are to display behavior comparable to human intelligent behavior. By integrating norms and individual intelligen...

In this paper we critically analyze the use of multiagent systems for performing simulations of biological processes. From the one hand, the possibility of associating different elements of a biological process to independent computing entities, called agents, makes multiagent systems a powerful and flexible tool for simulation. From the other hand, the weak validation of the results obtained m...

A multiagent system is one in which multiple autonomous agents interact to solve complex tasks. Each agent in a multiagent system has its own set of goals. The central problem addressed in this paper is coordination in multiagent systems. Coordination is a process by which, a system of agents work together harmoniously. The focus of this paper is on two types of coordination, resource coordinat...

The multiagent approach allows to effectively address and manage the complex regulation of physiological processes. In this paper we argue why multiagent regulating systems need to be simulated in order to assess the properties of interest. In particular, we consider a multiagent regulator of the glucose-insulin metabolism and we show how the effectiveness of its control activity and other sali...

Given the autonomous nature of various decisionmaking entities in deregulated power systems, this paper embraces a paradigm based on software agents and multiagent systems for distributed rational decision-making in electric power systems. Our current effort in this line of research is aimed at producing a platform-independent, robust application program interface for instantiating complex mult...

This paper presents an experience of a multiagent model formalization using coloured Petri nets, applied to the study of an hunting management system. The multiagent model of the hunting activity is presented, with simulation results. Then we describe Petri nets model assumptions and we give details about system modules. We analyze the model and we compare formal properties to multiagent simula...

In a retrospective review of 24 metastatic medulloblastoma patients whose treatment included craniospinal irradiation, 5 patients presented with gross residual abnormalities at completion of therapy. This report describes 2 medulloblastoma patients with persistent residual abnormalities on serial follow-up imaging studies. The patients aged 2 and 2.5 years old at the time of diagnosis underwent...

Metastatic disease is the most common mechanism of death in patients with advanced bladder cancer. As for most solid tumors, chemotherapy remains the only realistic option for palliating or curing metastatic disease. However, bladder cancer is characterized by chemoresistance. Only modest response rates are obtained using multiagent regimens including cisplatin. These low response rates and the...

We evaluated the proliferation, cytolytic function, and phenotypic characteristics of antLCD3 plus interleukin-2 (IL-2) stimulated peripheral blood mononuclear cells (PBMCs) from 44 patients with leukemia or non-Hodgkin's lymphoma (NHL) treated with multiagent chemotherapy or following bone marrow transplantation (BMT). BMT patients had decreased cell growth with only a 1.35 f 0.25 (autologous ...