Various isocyanide-based multicomponent reactions prove to be highly reliable when ?-substituted ?-amino boronic esters are employed as the amine component, allowing efficient synthesis of unprecedented peptidomimetics and heteroatom-rich boron-containing small molecules. In particular, scope Ugi reaction is widely exploited, give a family enantiopure ?-amido boronates. The Ugi-azide van Leusen...

Dihydropyrrolo[1,2-a]pyrazinone rings are a class of heterocycles present in wide range bioactive natural products and analogues thereof. As direct result their bioactivity, the synthesis this privileged compounds has been extensively studied. This review provides an overview these synthetic pathways. The literature is covered up until 2020 organized according to specific strategies used constr...

The tetrahydroquinolines obtained through the Povarov multicomponent reaction have been oxidized to the corresponding quinoline, giving access to a single product through a two-step sequence. Several oxidizing agents were studied and manganese dioxide proved to be the reagent of choice, affording higher yields, cleaner reactions and practical protocols.

Ring-opening of cyclic sulfamidates with propargylic sulfonamides yielded substrates for a gold-catalyzed cyclization to yield tetrahydropyrazines. Manipulation of the tetrahydropyrazines, by reduction or using multicomponent reactions, yielded piperazine scaffolds in which substitution of the carbon atoms was varied. Such scaffolds may have value in the synthesis of novel screening compounds w...

A  new  and  efficient  synthesis  of  2-amino-4H-chromene  derivativeswhich  have remarkable pharmacological properties  is  developed  by  one-pot  three-component  efficient  reaction  between aldehydes, malononitrile, and α or β-naphthol in MeOH as solvent using DABCO-CuCl complex as an  effective  catalyst  at  room  temperature. The  structures of  synthesized  compounds  were characteriz...

Ti-V-Nb-Cr alloys have been reported as potential candidates for hydrogen storage applications. Investigating the processes of absorption and desorption is paramount to understand properties these novel develop more efficient materials. In this work, we investigated absorption/desorption reactions (TiVNb)85Cr15 BCC multicomponent alloy by laboratory synchrotron X-ray diffraction, Pair Distribut...