This report describes a 23-year-old man who presented with multiple joint deformities as a consequence of multiple painless intra-articular fractures.Blood counts, biochemistry, and nerve conduction velocity were all normal. X-ray studies showed joint destruction in hips, elbows and knees.We concluded that he is a case of congenital insensitivity to pain culminating in multiple charcot joints.

In practice, gear backlash and bearing clearance usually exist together in a system. They may induce complicated dynamic responses degrade transmission performance. Up to now, although each of them has been researched, little attention paid the coupling characteristics clearance. limited number relevant studies, since linear collision models they adopted are difficult realistically depict actua...

The current study assesses hepatic and intestinal glucuronidation, sulfation, and cytochrome P450 (P450) metabolism of raloxifene, quercetin, salbutamol, and troglitazone using different in vitro systems. The fraction metabolized by conjugation and P450 metabolism was estimated in liver and intestine, and the importance of multiple metabolic pathways on accuracy of clearance prediction was asse...

INTRODUCTION The performance of ultrasound (US) in the diagnosis of acute gouty (MSU) arthritis and calcium pyrophosphate (CPP) arthritis is not yet well defined. Most studies evaluated US as the basis for diagnosing crystal arthritis in already diagnosed cases of gout and few prospective studies have been performed. METHODS One hundred nine consecutive patients who presented an acute arthrit...

background: measurement of absolute or differential renal function using radiotracers plays an important role in the clinical management of various renal diseases. gamma camera quantitative methods in approximation of renal clearance may potentially be as accurate as plasma clearance methods. however some critical factors such as kidney depth and background counts are still troublesome in the u...

abstract background: clearing the endotracheal tube through suctioning should be done to promote oxygenation. depth of suctioning is one of the variables in this regard. in shallow suctioning method, the catheter passes to the tip of the endotracheal tube, and in deep suctioning method, it passes beyond the tip into the trachea or brunches. this study aimed to evaluate the effect of shallow and...

Hollow organs lined by columnar epithelial cells normally secrete mucins and their proteolytic fragments vectorially into the lumen. These heterogeneously O-glycosylated molecules are known to aberrantly enter the bloodstream in the setting of epithelial carcinomas and possibly during injury or inflammation. We have recently shown that carcinoma mucin fragments can trigger the rapid formation o...

objective(s) as there are conflicting findings regarding the clearance-dose and patient characteristics relationships for valproic acid (vpa), this study was conducted to investigate the relationship between patient demographic characteristics, vpa dosage and the drug clearance in adult iranian patients. materials and methods patients (n= 47) were either on monotherapy with vpa or were under co...