Model systems have previously been developed in which herpes simplex virus (HSV) is retained in human fibroblasts in a nonreplicating state known as quiescence. The HSV type 1 (HSV-1) immediate-early (IE) protein ICP0, an important activator of gene expression, reactivates the quiescent genome and promotes the resumption of virus replication. Previous studies reported that infection with ICP0-n...

Helicobacter pylori infection of the human stomach causes chronic gastritis that can lead to gastric cancer. Because activated lymphocytes persist in the gastric mucosa, and because a high multiplicity of infection (MOI) of H. pylori is needed to induce apoptosis in vitro, we speculated that resistance of lymphocytes to apoptosis is an important feature of the immune response to H. pylori. Fres...

The concept of bacteriophage multiplicity of infection (MOI) - ratios of phages to bacteria - historically has been less easily applied than many phage workers would prefer or, perhaps, may be aware. Here, toward clarification of the concept, I discuss multiplicity of infection in terms of semantics, history, mathematics, pharmacology, and actual practice. For phage therapy and other biocontrol...

The ability to transfer immunoregulatory, cytoprotective, or antiapoptotic genes into pancreatic islet cells may allow enhanced posttransplantation survival of islet allografts and inhibition of recurrent autoimmune destruction of these cells in type 1 diabetes. However, transient transgene expression and the tendency to induce host inflammatory responses have limited previous gene delivery stu...

substantial movement is one of the most important sides of the gnostic geometry of the transcendental philosophy. in this writing, the notional aspect of the discourse and the way the substantial movement is based on the principality of existence is discussed. given the multiplicity of impressions from the principality of existence and the mentally-positedness (i‘tibāriyyat) of quiddity (māhiyy...

patients and methods the study population consisted of all patients with type iiia gastilo open fractures of tibial shaft, with or without fibula fracture (caused by trauma). after wound irrigation, debridement, and wound swab sampling for microbial culture, all patients received prophylactic antibiotic regimens in fitting with their wound class. no topical antibiotics were used with a 6-month ...

background :the present study was conducted to establish the patterns and risk factors of surgical site infections in our institution between 2006 and 2011.   methods: this was a retrospective cross-sectional study. the surgical site infection (ssi) was identified based on the presence of icd-10-cm diagnostic code in hospital discharge records. by using a standardized data collection form predi...

in this paper, we study the multiplicity of positive solutions for the laplacian systems with sign-changing weight functions. using the decomposition of the nehari manifold, we prove that an elliptic system has at least two positive solutions.

In this paper, we consider a coupled system of nonlinear fractional differential equations (FDEs), such that both equations have a particular perturbed terms. Using emph{Leray-Schauder} fixed point theorem, we investigate the existence and multiplicity of positive solutions for this system.