conclusions these results suggest that treadmill training and yoga practice improved ambulatory function, fatigue and mood status in the individuals with mild to moderate ms. patients and methods thirty-one ms patients, all female with mean of age of 36.75 years and expanded disability status scale scores (edss) of 1.0 to 4.0 were recruited. subjects were randomly assigned to one of the three g...

multiple sclerosis (ms) is a demyelinating neuro- inflammatory autoimmune disease of the central nervous system. genetic predisposition has long been suspected in the etiology of this disease. the association between mthfr polymorphisms and ms has been ivestigated in different ethnic groups. we investigated the association between mthfr c677t and a1298c missense variants and ms in 180 patients ...

background: hormones can play a significant role in the pathogenesis of multiple sclerosis (ms). the aim of this study was to compare levels of ghrelin, leptin, and testosterone hormones of ms patients with healthy subjects, and assess the relationship between levels of peptide hormone and sex hormones in ms patients. methods: 35 ms patients with definite relapsing remitting multiple sclerosis ...

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Disease progression in multiple sclerosis occurs within the interface of glial activation and gliosis. This study aimed to investigate the relationship between biomarkers of different glial cell responses: (i) to disease dynamics and the clinical subtypes of multiple sclerosis; (ii) to disability; and (iii) to cross-validate these findings in a post-mortem study. To address the first goal, 51 p...

Tuberous sclerosis complex manifests predominantly as a neurocutaneous disorder Lung involvement was considered rare. Lymphangioleiomyomatosis which occurs mainly in women of childbearing age is the major pulmonary disorder seen in tuberous sclerosis. Multifocal micronodular pneumocyte hyperplasia has also been described in tuberous sclerosis. The case of a 51-year old female diagnosed with tub...

Tumour necrosis factor alpha gene (TNF-alpha)-376 polymorphism in Hungarian patients with primary progressive multiple sclerosis. APOE epsilon status in Hungarian patients with primary progressive multiple sclerosis. Validation of the Fatigue Impact Scale in Hungarian patients with multiple sclerosis. Qual Life Res. Factors influencing the health-related quality of life in Hungarian multiple sc...

BACKGROUND Hand grip strength in both the dominant and non-dominant hands is often used to assess upper limb impairment. Excessive hand grip fatigability is another important measure, as fatigability may also influence activities of daily living. OBJECTIVE To investigate to what extent hand grip fatigability in multiple sclerosis is dependent on hand dominance, muscle strength and disease pro...

PURPOSE Systemic sclerosis is a life-threatening autoimmune disease characterized by vasculopathy, which results in myocardial involvement in an extremely high percentage of patients. Nevertheless, there have been no large-scale epidemiological studies about the risk of acute myocardial infarction in patients with systemic sclerosis. The aims of this study were to evaluate the hazard ratio (HR)...

BACKGROUND Although multiple sclerosis is considered as an inflammatory demyelinating disease of young adults, nearly 3% of patients manifest it under the age of 16 years. The aim of this study was to highlight the clinical and demographic features of early-onset multiple sclerosis in Isfahan, Iran. METHODS This prospective study concerned multiple sclerosis patients in whom the disease start...