of such regulatory (or suppressor) T cells has been a Our immune system protects us from a myriad of potengreat controversy among immunologists and has been tially pathogenic microorganisms while avoiding regiven little credibility for many years, largely because of acting with constituents of our body; i.e., we are tolerant the paucity of reliable markers for defining the cell, the of “self.” ...

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease which attacks the motor system. There is a family history in approximately 10% percent of cases and 20% of such families have point mutations in the Cu, Zn superoxide dimutase 1 (SOD1) gene. Pre-symp‐ tomatic loss of motor neurons has been identified prior to the onset of symptoms in SOD1 mice. This loss was biphasic with ...

e-amino group of lysine residues in substrate proteins. In many cases, this ubiquitination complex catalyzes the formation of a polyubiquitin chain on the substrate. Jeffrey D. Laney and Mark Hochstrasser* University of Chicago Department of Biochemistry and Despite this fairly well-characterized enzymatic pathMolecular Biology way for ubiquitin conjugation, how proteins are selected Chicago, I...

Wiley, John W., Hylan C. Moises, Robert A. Gross, and Robert sensory afferent neurons and antagonize transmission of noL. Macdonald. Dynorphin A-mediated reduction in multiple calciceptive information entering CNS presumably via their cium currents involves a Goa-subtype G protein in rat primary action to reduce calcium currents. The N-type channels are afferent neurons. J. Neurophysiol. 77: 13...

In cuts, infection with T-lymphotropic retroviruses can cause T-cell proliferation and leukemia or 7'-cell depletion and immunosuppression. In humans, some highly T4 tropic retroviruses called HTLV-I cun cuuse T-cell proliferation and leukrmiu. The subgroup HTLV-I1 ulso induces T-cell prol(ferution in vitro, but its role in disease is uncleur. Viruses of u third subgroup of humun T-lymphotropic...

In cuts, infection with T-lymphotropic retroviruses can cause T-cell proliferation and leukemia or 7'-cell depletion and immunosuppression. In humans, some highly T4 tropic retroviruses called HTLV-I cun cuuse T-cell proliferation and leukrmiu. The subgroup HTLV-I1 ulso induces T-cell prol(ferution in vitro, but its role in disease is uncleur. Viruses of u third subgroup of humun T-lymphotropic...

Four different kinds of data from the 3-methylcholanthrene-induced sarcoma system of the mouse show that the immune system stimulates oncogenesis; i.e., the presence of a tumor-specific immune reaction is a positive aid to tumor development. It seems proper, therefore, to consider cancer, at least in part, an autoimmune disease. The purpose of this paper is to review recent work supporting the ...

may represent initial attacks of MS that are self-conExperimental autoimmune encephalomyelitis (EAE) is a tained. useful model of acute demyelinating disease. Some There are three acute demyelinating diseases affectforms of EAE reflect chronic demyelination with exacering the CNS—acute optic neuritis (AON), acute transverse bations and remissions characteristic of multiple scleromyelopathy (ATM...