Regular resistance exercise induces skeletal muscle hypertrophy and improvement of glycemic control in type 2 diabetes patients. Administration of dehydroepiandrosterone (DHEA), a sex steroid hormone precursor, increases 5α-dihydrotestosterone (DHT) synthesis and is associated with improvements in fasting blood glucose level and skeletal muscle hypertrophy. Therefore, the aim of this study was ...

TO DETERMINE whether, in certain aspects, hypertrophied heart muscle behaves differently from normal heart muscle simple observations were performed. Papillary muscle strips from the left ventricle of rats, the hearts of which had been caused to hypertrophy, were compared with papillary strips from normal rat hearts by measuring tension developed at various weights in a perfused isolated muscle...

An inverse relationship between skeletal muscle fiber cross-sectional area (CSA) and oxidative capacity suggests that muscle fibers hypertrophy at the expense of oxidative capacity. Therefore, our objective was to utilize pigs possessing mutations associated with increased oxidative capacity [AMP-activated protein kinase (AMPKγ3(R200Q))] or fiber hypertrophy [ryanodine receptor 1 (RyR1(R615C))]...

Muscle growth requires a population(s) of myogenic progenitor cells (MPCs) or myoblasts that remain capable of proliferation and are regulated by signaling pathways responsive to both nutritional status and environmental conditions. Myotube formation involves the recognition and adhesion of myoblasts, the breakdown of muscle membranes and the remodeling of the actin cytoskeleton. Myotube produc...

Unilateral posterior crossbite is a malocclusion disease that involves morpho-functional characteristics of masseter muscle; normal or increased activity contralateral muscle and reduced the ipsilateral during unilateral have been shown. Since extracellular matrix plays key role in mechano-transduction transmitting forces contraction, aim present study was to analyse behaviour this type through...

Hypertrophy is undoubtedly the most important problem in the structural adaptation of heart muscle. It stands at the centre of medical discussion because it is just the hypertrophic heart muscle that, after performing efficiently for a long time, finally fails. For this reason structural researches into hypertrophy include those of myocardial failure (Buchner, I950, I96I). According to the macr...

Deviation from proper muscle development or homeostasis results in various myopathic conditions. Employing genetic as well as chemical intervention, we provide evidence that a tight regulation of Wnt/beta-catenin signaling is essential for muscle fiber growth and maintenance. In zebrafish embryos, gain-of-Wnt/beta-catenin function results in unscheduled muscle progenitor proliferation, leading ...

Mice genetically deficient in growth and differentiation factor 8 (GDF8/myostatin) had markedly increased muscle fiber numbers and fiber hypertrophy. In the regenerating muscle of mice possessing FGF6 mutation, fiber remodeling was delayed. Although myostatin and FGF6 may be important for the maintenance, regeneration and/or hypertrophy of muscle, little work has been done on the possible role ...

The muscle-specific RING finger proteins MuRF1 and MuRF2 have been proposed to regulate protein degradation and gene expression in muscle tissues. We have tested the in vivo roles of MuRF1 and MuRF2 for muscle metabolism by using knockout (KO) mouse models. Single MuRF1 and MuRF2 KO mice are healthy and have normal muscles. Double knockout (dKO) mice obtained by the inactivation of all four MuR...