Skeletal muscle injuries are the most common sports-related injuries in sports medicine. In this work, we have generated a new surgically-induced skeletal muscle injury in rats, by using a biopsy needle, which could be easily reproduced and highly mimics skeletal muscle lesions detected in human athletes. By means of histology, immunofluorescence and MRI imaging, we corroborated that our model ...

TO THE EDITOR: Interpretations on the effect of estrogen/sex should be based on direct measures of muscle injury and subsequent repair/regeneration (i.e., improvements in muscle structure and function after injurious exercise). The inclusion of indexes of the inflammatory response (e.g., accumulation of neutrophils and/or macrophages) and inflammation (e.g., edema) into the discussion seems to ...

We have shown that muscle-derived stem cells (MDSCs) transplanted into dystrophic (mdx) mice efficiently regenerate skeletal muscle. However, MDSC populations exhibit heterogeneity in marker profiles and variability in regeneration abilities. We show here that cell sex is a variable that considerably influences MDSCs' regeneration abilities. We found that the female MDSCs (F-MDSCs) regenerated ...

BACKGROUND Children with a cleft in the soft palate have difficulties with speech, swallowing, and sucking. Despite successful surgical repositioning of the muscles, optimal function is often not achieved. Scar formation and defective regeneration may hamper the functional recovery of the muscles after cleft palate repair. Therefore, the aim of this study is to investigate the anatomy and histo...

During salamander limb regeneration, only the structures distal to the amputation plane are regenerated, a property known as the rule of distal transformation. Multiple cell types are involved in limb regeneration; therefore, determining which cell types participate in distal transformation is important for understanding how the proximo-distal outcome of regeneration is achieved. We show that c...

OBJECTIVE To characterise morphological abnormalities in relation to muscle fibre type in sporadic inclusion body myositis (s-IBM). METHODS 14 muscle biopsies from 11 patients with s-IBM were characterised for morphological abnormalities and fibre type composition as well as muscle fibre regeneration and cytoskeletal structure, using histochemical and immunohistochemical techniques. RESULTS...

In 1865 Waldeyer pointed out that regeneration of skeletal muscle can occur after injury. Since then, others have shown that muscle regeneration may follow various types of damage including trauma (Weber 1867, Neumann 1868), ischaemia (Clark and Blomfield 1945), and toxic degeneration (Hoffman 1867, Forbus 1926). More recently the details of the histological processes involved have been describ...