Initial genetic studies in Drosophila suggested that several members of the Rho subfamily (RhoA, Rac1 and Cdc42) are involved in planar cell polarity (PCP) establishment. However, analyses of Rac1, Rac2 and Mtl loss-of-function (LOF) mutants have argued against their role in this process. Here, we investigate in detail the role of the Rho GTPases Mtl, Cdc42, Rac1 and Rac2 in PCP generation. The...

The Microsystems Technology Laboratories (MTL) is an interdepartmental laboratory with a mission to foster research and education in semiconductor process and device technology, and in integrated circuits and systems design. MTL provides microand nanofabrication and computer-aided design (CAD) infrastructure to the entire campus. MTL has 43 core faculty members who are engaged in diverse resear...

Studies of cognitive and neural aging have recently provided evidence of a shift from an early- to late-onset cognitive control strategy, linked with temporally extended activity in the prefrontal cortex (PFC). It has been uncertain, however, whether this age-related shift is unique to PFC and executive control tasks or whether the functional location might vary depending on the particular cogn...

Candida albicans, which is diploid, possesses a single mating-type (MTL) locus on chromosome 5, which is normally heterozygous (a/alpha). To mate, C. albicans must undergo MTL homozygosis to a/a or alpha/alpha. Three possible mechanisms may be used in this process, mitotic recombination, gene conversion, or loss of one chromosome 5 homolog, followed by duplication of the retained homolog. To di...

In the present PET study, we examined brain activity related to processing of pictures and printed words in episodic memory. Our goal was to determine how the perceptual format of objects (verbal versus pictorial) is reflected in the neural organization of episodic memory for common objects. We investigated this issue in relation to encoding and recognition with a particular focus on medial tem...

fuzzy logic, 67algebraic semantics, 53approximate reasoning, 6axiomatic extensions of MTL, 56 Bellman, R., 21bipolar possibilistic logic, 93BL logic, 51 canonical chain, 66canonical completeness, 66canonical extension, 83Carnap, R., 3comparative truth, 63compositionality, 29computational complexity, 73core fuzzy logic, 58 De Finetti B., 3degre...

The functional magnetic resonance imagery responses of declarative memory tasks in the medial temporal lobe (MTL) are examined by using large deformation diffeomorphic metric mapping (LDDMM) to remove anatomical variations across subjects. LDDMM is used to map the structures of the MTL in multiple subjects into extrinsic atlas coordinates; these same diffeomorphic mappings are used to transfer ...

The medial temporal lobe (MTL) has been studied extensively at all levels of analysis, yet its function remains unclear. Theory regarding the cognitive function of the MTL has centered along 3 themes. Different authors have emphasized the role of the MTL in episodic recall, spatial navigation, or relational memory. Starting with the temporal context model (M. W. Howard & M. J. Kahana, 2002a), a...

Multi-task learning (MTL) has recently contributed to learning better representations in service of various NLP tasks. MTL aims at improving the performance of a primary task, by jointly training on a secondary task. This paper introduces automated tasks, which exploit the sequential nature of the input data, as secondary tasks in an MTL model. We explore next word prediction, next character pr...

Existing deep multitask learning (MTL) approaches align layers shared between tasks in a parallel ordering. Such an organization significantly constricts the types of shared structure that can be learned. The necessity of parallel ordering for deep MTL is first tested by comparing it with permuted ordering of shared layers. The results indicate that a flexible ordering can enable more effective...