Members of the genus Mycobacterium are the most prevalent cause of infectious diseases. Mycobacteria have a complex cell envelope containing a peptidoglycan layer and an additional arabinogalactan polymer to which a mycolic acid bilayer is linked; this complex, multilayered cell wall composition (mAGP) is conserved among all CMN group bacteria. The arabinogalactan and mycolic acid synthesis pat...

In the case of vitamin Kr, anaerobic incubation of the quinone with an electron donor and a Alycobacterium phlei preparation yielded a reduced phosphorylated derivative (3) which underwent enzymatic autoxidation to vitamin K with release of inorganic phosphate; this was stated to be a naphthochromanyl phosphate. The 6-chromanyl phosphate (111) of vitamin K1c20) has been synthesized (10) and sho...

It has been demonstrated that the terminal electron transport pathway of Mycobacttium phlei resides in a particulate fraction of the organism (1). Evidence also has been obtained suggesting that a naturally occurring naphthoquinone is involved as an oxidation-reduction component in this pathway (2). Since a naphthoquinone may be involved in this system, the possibility exists that naphthosemiqu...

Background: We have previously reported the results of a prospective multi-institutional study on the efficacy of MCNA in patients who recurred after intravesical BCG treatment [1]. Since that publication, a new standardized definition for BCG-unresponsiveness has been established [2]. Objective: We re-analyzed the oncologic outcomes following intravesical MCNA in patients classified as BCG-unr...

It has been observed that mycobacterial species has high content of cardiolipin (CL) in their cell membranes more so pathogenic mycobacteria and in bacteria CL activates polymerases, gyrases by removing the bound ADP. Therefore, in the present study cardiolipin synthase (cls) which catalyses the formation of CL was isolated purified and characterized from the cell membrane of Mycobacterium phle...

Rabbit serum is the most important constituent in culture media for the growth of pathogenic leptospires. Many reports have shown that fatty acid or lipid fractions supported the growth of leptospires in place of rabbit serum [I. Mifuchi and T. Kawata, Med. Biol. (Tokyo) 28:128, 1953; H. Woratz, Zentr. Bakteriol. Parasitenk. Abt. I Orig. 162:106, 1955; 169:269, 1957; R. C. Johnson and J. B. Wil...