Multiple Sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS). MS is characterized by an immune response directed against myelin sheath. This immune response results in demyelination, which leads to the clinical symptoms of MS. It is accepted that MS is mediated by T helper 1/ T helper 17 immune responses. However, the role of B cells and antibodies (Abs) ar...

Here we report the isolation and initial biochemical characterization of a 120-kD peanut agglutinin-binding glycoprotein from the adult human central nervous system (CNS), which is anchored to membranes through a phosphatidylinositol linkage. Myelin incubated with phosphatidylinositol-specific phospholipase C released the protein as a soluble polypeptide of 105 kD, which was isolated with peanu...

Background: Idiopathic longitudinally extensive transverse myelitis is defined as a focal spinal cord lesion that involves three or more segments of the shown by neuroimaging, and results in profound disability. The clinical picture patient with idiopathic advanced often dramatic may consist paraparesis tetraparesis, sensory disturbances, pelvic dysfunction. common manifestation neuromyelitis o...

Since Río-Hortega's description of oligodendrocyte morphologies nearly a century ago, many studies have observed myelin sheath-length diversity between CNS regions. Myelin sheath length directly impacts axonal conduction velocity by influencing the spacing between nodes of Ranvier. Such differences likely affect neural signal coordination and synchronization. What accounts for regional differen...